Document Detail

Estrogen induces expression of c-jun and jun-B protooncogenes in specific rat uterine cells.
MedLine Citation:
PMID:  8319568     Owner:  NLM     Status:  MEDLINE    
Expression of the protooncogene c-jun is induced in the uteri of ovariectomized rats in response to treatment with 17 beta-estradiol (E2-17 beta). E2 also specifically induces the uterine expression of jun-B-encoding mRNA. Medroxyprogesterone acetate and testosterone propionate treatment had no effect on the expression of c-jun- and jun-B-encoding mRNAs. Dexamethasone treatment, however, induced expression of c-jun mRNA, although less than that observed in response to E2. Cycloheximide treatment failed to block the E2-induced expression of c-jun and jun-B mRNAs, indicating that these were immediate early responses. E2-16 alpha, a short-acting estrogen, also induced c-jun and jun-B mRNA expression. The expression of c-Jun protein was examined by immunohistological methods and detected in all uterine cell types in response to treatment with estrogen. The Jun-B protein, however, was localized in uterine epithelial cells. The results of these experiments suggest that the cell type-specific expression of members of the jun family of protooncogenes may be an important regulatory event in the response of the uterus to estrogen.
D K Webb; B C Moulton; S A Khan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Endocrinology     Volume:  133     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-08-03     Completed Date:  1993-08-03     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  20-8     Citation Subset:  AIM; IM    
Department of Anatomy and Cell Biology, University of Cincinnati College of Medicine, Ohio 45267-0521.
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MeSH Terms
Blotting, Northern
Cycloheximide / pharmacology
Dexamethasone / pharmacology
Estradiol / pharmacology*
Gene Expression / drug effects*
Genes, jun / genetics*
Medroxyprogesterone Acetate / pharmacology
RNA, Messenger / metabolism
Rats, Sprague-Dawley
Testosterone / pharmacology
Uterus / drug effects,  metabolism*
Grant Support
Reg. No./Substance:
0/RNA, Messenger; 50-02-2/Dexamethasone; 50-28-2/Estradiol; 58-22-0/Testosterone; 66-81-9/Cycloheximide; 71-58-9/Medroxyprogesterone Acetate

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