| Estrogen exposure and bladder cancer risk in Egyptian women. | |
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MedLine Citation:
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PMID: 20813471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine associations between reproductive history and urinary bladder cancer in Egyptian women. METHODS: We used questionnaire data from an ongoing, multicenter case-control study in Egypt. Controls were matched on age and residence area. This analysis focused on female cases with confirmed urothelial (UC) and squamous cell (SCC) carcinoma of the bladder. RESULTS: We recruited 779 women (540 controls, 239 cases; >98.0% nonsmokers). Younger age at menopause (<45 y) and older age at first pregnancy (>18 y) were factors significantly associated with increased risk of bladder cancer, even after adjusting for schistosomiasis history and other covariates in the multivariable logistic model; adjusted odds ratio and 95% confidence intervals were 1.98 (1.41, 2.77) and 6.26 (3.46, 11.34), respectively. On the other hand, multiple pregnancies or use of oral contraceptives were associated with decreased odds of having bladder cancer. Similar associations were observed with UC and SCC when analyzed separately; however, the magnitude of association with SCC was lower than with UC. CONCLUSION: Our data suggest that early estrogen exposure, or the relative lack of it, plays a role in urinary bladder carcinoma development among Egyptian women. |
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Authors:
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Beverly J Wolpert; Sania Amr; Sameera Ezzat; Doa'a Saleh; Iman Gouda; Iman Loay; Tamer Hifnawy; Nabiel N Mikhail; Mohamed Abdel-Hamid; Min Zhan; Yun-Ling Zheng; Katherine Squibb; Mohamed A Abdel-Aziz; Mohamed Zaghloul; Hussein Khaled; Christopher A Loffredo |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-09-01 |
Journal Detail:
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Title: Maturitas Volume: 67 ISSN: 1873-4111 ISO Abbreviation: Maturitas Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-29 Completed Date: 2011-05-11 Revised Date: 2012-09-28 |
Medline Journal Info:
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Nlm Unique ID: 7807333 Medline TA: Maturitas Country: Ireland |
Other Details:
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Languages: eng Pagination: 353-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. bwolpert@epi.umaryland.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Carcinoma, Squamous Cell / etiology* Case-Control Studies Contraceptives, Oral* / adverse effects Egypt Estrogens / adverse effects, metabolism* Female Humans Logistic Models Menarche Middle Aged Multivariate Analysis Odds Ratio Pregnancy* Pregnancy, Multiple* Questionnaires Reproductive History* Risk Factors Urinary Bladder Neoplasms / etiology* |
| Grant Support | |
ID/Acronym/Agency:
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5R01-CA115618-03/CA/NCI NIH HHS; R01 CA115618/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contraceptives, Oral; 0/Estrogens |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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