Document Detail

Estrogen deficiency and risk of Alzheimer's disease in women.
MedLine Citation:
PMID:  8030628     Owner:  NLM     Status:  MEDLINE    
The authors explored the possibility that estrogen loss associated with menopause may contribute to the development of Alzheimer's disease by using a case-control study nested within a prospective cohort study. The Leisure World Cohort includes 8,877 female residents of Leisure World Laguna Hills, a retirement community in southern California, who were first mailed a health survey in 1981. From the 2,529 female cohort members who died between 1981 and 1992, the authors identified 138 with Alzheimer's disease or other dementia diagnoses likely to represent Alzheimer's disease (senile dementia, dementia, or senility) mentioned on the death certificate. Four controls were individually matched by birth date (+/- 1 year) and death date (+1 year) to each case. The risk of Alzheimer's disease and related dementia was less in estrogen users relative to nonusers (odds ratio = 0.69, 95 percent confidence interval 0.46-1.03). The risk decreased significantly with increasing estrogen dose and with increasing duration of estrogen use. Risk was also associated with variables related to endogenous estrogen levels; it increased with increasing age at menarche and (although not statistically significant) decreased with increasing weight. This study suggests that the increased incidence of Alzheimer's disease in older women may be due to estrogen deficiency and that estrogen replacement therapy may be useful for preventing or delaying the onset of this dementia.
A Paganini-Hill; V W Henderson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of epidemiology     Volume:  140     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-08-11     Completed Date:  1994-08-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  256-61     Citation Subset:  IM    
Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles 90031.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / epidemiology,  etiology*
Case-Control Studies
Estrogen Replacement Therapy*
Estrogens / deficiency*
Odds Ratio
Prospective Studies
Risk Factors
Grant Support
Reg. No./Substance:

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