Document Detail


Estrogen and the cholinergic system modulate visuospatial attention in monkeys (Macaca fascicularis).
MedLine Citation:
PMID:  11996304     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study determined the effects of estrogen on attention and motor speed in young monkeys (Macaca fascicularis). Performance on visuospatial attention and reaction time motor tasks was measured before ovariectomy, for 2 months after ovariectomy, and at 14 months after treatment with placebo or estrogen replacement therapy (ERT). Release time on invalid trials in the attention task was increased after ovariectomy and was reduced in monkeys treated with ERT. but not placebo. Simple reaction time was not altered after ovariectomy or treatment. The effects of scopolamine on attention, but not memory, in a delayed response task were dependent on estrogen. These observations indicate that loss of estrogen modulates visuospatial attention in primates and that 1 mechanism of this modulation is through the cholinergic system.
Authors:
Mary Lou Voytko
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  116     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-05-08     Completed Date:  2002-10-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  187-97     Citation Subset:  IM    
Affiliation:
Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1040, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Attention / drug effects*
Choline / metabolism*
Estrogen Replacement Therapy / methods
Estrogens / metabolism*
Female
Macaca fascicularis
Muscarinic Antagonists / pharmacology*
Ovariectomy
Scopolamine / pharmacology*
Space Perception / drug effects*
Visual Perception / drug effects*
Grant Support
ID/Acronym/Agency:
AG13204/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Estrogens; 0/Muscarinic Antagonists; 51-34-3/Scopolamine; 62-49-7/Choline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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