Document Detail


Estrogen blocks neurotoxic effects of beta-amyloid (1-42) and induces neurite extension on B103 cells.
MedLine Citation:
PMID:  9406879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clinical studies have shown that estrogen replacement therapy is associated with reduced risk of Alzheimer's disease (AD). We tested whether or not estrogen blocks neurotoxic effects of beta-amyloid (1-42) (A beta1-42) on cultured B103 cells. A beta1-42 (1 microM) induced typical necrotic cell death, as revealed by light and electron microscopic examinations. Co-administration of estrogen not only blocked A beta1-42 toxicity to a large degree, but also enhanced neurite extension. Pretreatment with estrogen was even more effective in blocking A beta1-42 toxicity. When added 18 h after the beginning of A beta1-42 treatment, estrogen was still effective in halting the progress of cell death and enhancing neurite extension. The protection against A beta1-42-induced neuronal death by estrogen was unlikely due to a blockade of lipid peroxidation injury, since estrogen completely failed to attenuate ferrous chloride-induced cell death. These results demonstrate that estrogen blocks A beta1-42-induced neurotoxicity and enhances neurite extension on B103 cells, both of which may well be underlying mechanisms of beneficial effects of estrogen in AD.
Authors:
I Mook-Jung; I Joo; S Sohn; H J Kwon; K Huh; M W Jung
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  235     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1998-01-29     Completed Date:  1998-01-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  101-4     Citation Subset:  IM    
Affiliation:
Department of Neurology, School of Medicine, Institute for Medical Sciences, Ajou University, Suwon, South Korea. inhee@skull.ajou.ac.kr
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MeSH Terms
Descriptor/Qualifier:
Amyloid beta-Protein / antagonists & inhibitors,  toxicity*
Animals
Brain / cytology,  drug effects*
Cell Line
Estrogens / pharmacology*
Neurites / drug effects*
Neurons / drug effects*,  ultrastructure
Neurotoxins / toxicity*
Peptide Fragments / antagonists & inhibitors,  toxicity*
Rats
Chemical
Reg. No./Substance:
0/Amyloid beta-Protein; 0/Estrogens; 0/Neurotoxins; 0/Peptide Fragments; 0/amyloid beta-protein (1-42)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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