| Estrogen and androgen concentrations are not lower in the umbilical cord serum of pre-eclamptic pregnancies. | |
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MedLine Citation:
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PMID: 14652293 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reductions in breast cancer risk observed in daughters of pre-eclamptic pregnancies are hypothesized to be mediated by lower in utero estrogen concentrations. Whereas maternal urinary estriol excretion is generally lower in pre-eclamptic women, results for maternal blood concentrations are equivocal, and little is known about estrogen concentrations in the cord of pre-eclamptic pregnancies. Unconjugated estrogen and androgen concentrations were measured in mixed umbilical cord sera from 86 pre-eclamptic and 86 uncomplicated, singleton pregnancies, matched on length of gestation, maternal age, parity, and type of delivery. Pre-eclamptic and uncomplicated pregnancies were similar in maternal age, prepregnancy weight, maternal height, type of delivery, use and type of anesthesia, and sex of offspring. Estriol, estradiol, estrone, dehydroepiandrosterone, dehydroepiandrosterone-sulfate, androstenedione, and testosterone concentrations measured in cord sera were not significantly different in pre-eclamptics compared with uncomplicated pregnancies. Estriol was 9% lower (P = 0.43), and all of the other hormones were actually higher in pre-eclamptics with testosterone and estradiol approaching statistical significance (P = 0.06 and P = 0.12, respectively). These data do not support the hypothesis that the lower breast cancer risk in daughters of pre-eclamptic pregnancies is explained by lower in utero estrogen exposure. |
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Authors:
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Rebecca Troisi; Nancy Potischman; Christine Neuser Johnson; James M Roberts; David Lykins; Gail Harger; Nina Markovic; Pentti Siiteri; Robert N Hoover |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Volume: 12 ISSN: 1055-9965 ISO Abbreviation: Cancer Epidemiol. Biomarkers Prev. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-12-03 Completed Date: 2004-03-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9200608 Medline TA: Cancer Epidemiol Biomarkers Prev Country: United States |
Other Details:
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Languages: eng Pagination: 1268-70 Citation Subset: IM |
Affiliation:
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Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA. troisir@mail.nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Androgens / blood* Breast Neoplasms / prevention & control* Estrogens / blood* Female Fetal Blood / chemistry* Humans Odds Ratio Pre-Eclampsia* Pregnancy Prenatal Exposure Delayed Effects* Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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2 P01-HD30367/HD/NICHD NIH HHS; 5 M01-RR00056/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Androgens; 0/Estrogens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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