Document Detail


Estrogen-androgen balance in anovulation.
MedLine Citation:
PMID:  7195829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The balance of estradiol (E2) and testosterone (T) in 15 anovulatory patients was evaluated by measuring the daily plasma concentration of E2 and T, and their free and protein-bound fractions for a 3- to 4-week period. Similar daily plasma E2 and T data were obtained from five normal ovulatory cycles as a control group. The daily concentration of the free, non-testosterone-estradiol-binding globulin (TeBG)-bound (index), and total E2 fluctuated in a wider range than that of the T in the ovulatory as well as in the anovulatory cycles. The percentage of free (%F) and TeBG-bound (%TeBG) fractions of both E2 and T were relatively constant. The concentration of the free, index, and total E2 and T showed a parallel pattern even in anovulatory cycles. An increased %F fraction associated with a decreased %TeBG fraction of E2 and T was observed in anovulatory patients who were hypo- or normoestrogenic; however, an opposite shifting of these two fractions was observed in anovulatory patients who were severely hypoestrogenic. In a hyperestrogen-normoandrogenic state, there was a significant increase in the binding of E2 and T. The daily binding capacity of plasma TeBG revealed a greater fluctuation than the binding fractions, and it decreased in anovulatory patients, especially in the hyperandrogenic state. E2:T ratio of concentration showed a curve-linear relationship to %F, %TeBG, and binding capacity of sex steroids.
Authors:
C H Wu; T Motohashi; H A Abdel-Rahman; G Mikhail
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  36     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1981-09-22     Completed Date:  1981-09-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  61-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anovulation / blood*
Estradiol / blood*
Female
Humans
Ovulation
Sex Hormone-Binding Globulin / analysis*
Testosterone / blood*
Chemical
Reg. No./Substance:
0/Sex Hormone-Binding Globulin; 50-28-2/Estradiol; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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