Document Detail


Estrogen receptor-α and estrogen receptor-β in the uterine vascular endothelium during pregnancy: functional implications for regulating uterine blood flow.
MedLine Citation:
PMID:  22271294     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The steroid hormone estrogen and its classical estrogen receptors (ERs), ER-α and ER-β, have been shown to be partly responsible for the short- and long-term uterine endothelial adaptations during pregnancy. The ER-subtype molecular and structural differences coupled with the differential effects of estrogen in target cells and tissues suggest a substantial functional heterogeneity of the ERs in estrogen signaling. In this review we discuss (1) the role of estrogen and ERs in cardiovascular adaptations during pregnancy, (2) in vivo and in vitro expression of ERs in uterine artery endothelium during the ovarian cycle and pregnancy, contrasting reproductive and nonreproductive arterial endothelia, (3) the structural basis for functional diversity of the ERs and estrogen subtype selectivity, (4) the role of estrogen and ERs on genomic responses of uterine artery endothelial cells, and (5) the role of estrogen and ERs on nongenomic responses in uterine artery endothelia. These topics integrate current knowledge of this very rapidly expanding scientific field with diverse interpretations and hypotheses regarding the estrogenic effects that are mediated by either or both ERs and their relationship with vasodilatory and angiogenic vascular adaptations required for modulating the dramatic physiological rises in uteroplacental perfusion observed during normal pregnancy.
Authors:
Mayra B Pastore; Sheikh O Jobe; Jayanth Ramadoss; Ronald R Magness
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-01-23
Journal Detail:
Title:  Seminars in reproductive medicine     Volume:  30     ISSN:  1526-4564     ISO Abbreviation:  Semin. Reprod. Med.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-24     Completed Date:  2012-05-14     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  100909394     Medline TA:  Semin Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  46-61     Citation Subset:  IM    
Copyright Information:
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Affiliation:
Department of Obstetrics/Gynecology, Perinatal Research Laboratories, University of Wisconsin-Madison, Madison, Wisconsin, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Endothelium, Vascular / cytology,  metabolism*
Epigenesis, Genetic
Estrogen Receptor alpha / agonists,  chemistry,  metabolism*
Estrogen Receptor beta / agonists,  chemistry,  metabolism*
Estrogens / metabolism
Female
Gene Expression Regulation
Humans
Ovary / cytology,  metabolism
Pregnancy / physiology*
Pregnancy Proteins / chemistry,  metabolism*
Protein Isoforms / agonists,  chemistry,  metabolism
Regional Blood Flow*
Signal Transduction
Uterine Artery / cytology,  metabolism
Uterus / blood supply*
Grant Support
ID/Acronym/Agency:
AA19446/AA/NIAAA NIH HHS; HD38843/HD/NICHD NIH HHS; HL49210/HL/NHLBI NIH HHS; HL89144/HL/NHLBI NIH HHS; P01 HD038843/HD/NICHD NIH HHS; R00 AA019446/AA/NIAAA NIH HHS; R01 HL049210/HL/NHLBI NIH HHS; R01 HL087144/HL/NHLBI NIH HHS; R25 GM083252/GM/NIGMS NIH HHS; R25-GM083252/GM/NIGMS NIH HHS; T32 HD041921/HD/NICHD NIH HHS; T32-HD041921-07/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Estrogen Receptor alpha; 0/Estrogen Receptor beta; 0/Estrogens; 0/Pregnancy Proteins; 0/Protein Isoforms; 0/estrogen receptor alpha, human
Comments/Corrections

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