| Estrogen paradox in pulmonary hypertension: current controversies and future perspectives. | |
| | |
MedLine Citation:
|
PMID: 22561960 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Although the incidence of pulmonary hypertension is higher in female patients, numerous experimental studies have demonstrated better outcome in female animals, exacerbation of the disease after ovariectomy, and a strong protective effect of estrogen: a phenomenon known as the "estrogen paradox" of pulmonary hypertension. On the other hand, some clinical studies have indirectly linked estrogen to increased risk of portopulmonary hypertension, whereas others implicate increased estrogen metabolism and high levels of certain estrogen metabolites in promoting pulmonary vascular remodeling in familial pulmonary arterial hypertension. In this review we investigate the estrogen paradox through highlighting the differential receptor-mediated effects of estrogen. Although estrogen and estrogen receptor-based therapies have shown promise in rescuing preexisting pulmonary hypertension in animals, their role is yet to be defined in humans. |
| | |
Authors:
|
Soban Umar; Marlene Rabinovitch; Mansoureh Eghbali |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2012-05-03 |
Journal Detail:
|
Title: American journal of respiratory and critical care medicine Volume: 186 ISSN: 1535-4970 ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2012 Jul |
Date Detail:
|
Created Date: 2012-07-16 Completed Date: 2012-10-03 Revised Date: 2013-04-16 |
Medline Journal Info:
|
Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: United States |
Other Details:
|
Languages: eng Pagination: 125-31 Citation Subset: AIM; IM |
Affiliation:
|
Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine at University of California, Los Angeles, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Estrogens / metabolism, physiology*, therapeutic use Female Humans Hypertension, Pulmonary / drug therapy, etiology, physiopathology* Male Rats Receptors, Estrogen / physiology Sex Factors Vasodilation / drug effects, physiology |
| Grant Support | |
ID/Acronym/Agency:
|
HL089876/HL/NHLBI NIH HHS; HL089876S1/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Estrogens; 0/Receptors, Estrogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: LV Dysfunction Induced by a Non-severe Idiopathic Pulmonary Arterial Hypertension. A Pressure-Volume...
Next Document: Resolution of Chylous Pulmonary Congestion and Respiratory Failure in LAM with Sirolimus Therapy.