Document Detail


Estrogen paradox in pulmonary hypertension: current controversies and future perspectives.
MedLine Citation:
PMID:  22561960     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although the incidence of pulmonary hypertension is higher in female patients, numerous experimental studies have demonstrated better outcome in female animals, exacerbation of the disease after ovariectomy, and a strong protective effect of estrogen: a phenomenon known as the "estrogen paradox" of pulmonary hypertension. On the other hand, some clinical studies have indirectly linked estrogen to increased risk of portopulmonary hypertension, whereas others implicate increased estrogen metabolism and high levels of certain estrogen metabolites in promoting pulmonary vascular remodeling in familial pulmonary arterial hypertension. In this review we investigate the estrogen paradox through highlighting the differential receptor-mediated effects of estrogen. Although estrogen and estrogen receptor-based therapies have shown promise in rescuing preexisting pulmonary hypertension in animals, their role is yet to be defined in humans.
Authors:
Soban Umar; Marlene Rabinovitch; Mansoureh Eghbali
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-05-03
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  186     ISSN:  1535-4970     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-16     Completed Date:  2012-10-03     Revised Date:  2013-07-17    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  125-31     Citation Subset:  AIM; IM    
Affiliation:
Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine at University of California, Los Angeles, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Estrogens / metabolism,  physiology*,  therapeutic use
Female
Humans
Hypertension, Pulmonary / drug therapy,  etiology,  physiopathology*
Male
Rats
Receptors, Estrogen / physiology
Sex Factors
Vasodilation / drug effects,  physiology
Grant Support
ID/Acronym/Agency:
HL089876/HL/NHLBI NIH HHS; HL089876S1/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Estrogens; 0/Receptors, Estrogen
Comments/Corrections

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