Document Detail

Estramustine phosphate--hormone, chemotherapeutic agent, or both?
MedLine Citation:
PMID:  6539998     Owner:  NLM     Status:  MEDLINE    
Estramustine phosphate, a combination steroid and alkylating agent, has been used for treatment of cancer of the prostate since 1969. We treated 32 patients with Stages C and D prostate cancer with this compound. Using the National Prostatic Cancer Project criteria of response, no patient achieved complete or partial objective response. Sixty-two per cent of the patients without prior hormonal manipulation and 12 per cent of those who were progressing following hormonal therapy met the criteria for a stable response. Both Stage C patients, 50 per cent of D1 and 28 per cent of D2 patients achieved disease stabilization for a mean duration of 14.8 months. There was no correlation between tumor grade and response to treatment. Fifty per cent of the patients whose elevated acid phosphatase declined remain stable, whereas 80 per cent in whom the acid phosphatase did not decline have progressed. Estramustine is effective in patients without prior hormonal manipulation. In those refractory to hormones, the prognosis is poor yet data exist to support the superiority of estramustine phosphate over conventional therapy.
Y Walzer; J Oswalt; M S Soloway
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Urology     Volume:  24     ISSN:  0090-4295     ISO Abbreviation:  Urology     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-08-03     Completed Date:  1984-08-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  53-8     Citation Subset:  IM    
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MeSH Terms
Carcinoma / drug therapy*
Estramustine / therapeutic use*
Middle Aged
Nitrogen Mustard Compounds / therapeutic use*
Prostatic Neoplasms / drug therapy*
Grant Support
Reg. No./Substance:
0/Hormones; 0/Nitrogen Mustard Compounds; 2998-57-4/Estramustine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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