| Estramustine binding protein in human brain-tumor tissue. | |
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MedLine Citation:
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PMID: 1709687 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Estramustine, an estradiol-17 beta and nornitrogen mustard complex, is used in the treatment of advanced prostatic carcinoma. A specific estramustine binding protein (EMBP) is important for its cytotoxic action, and the presence of EMBP has previously been demonstrated in rat and human prostatic cancer tissue. Significant levels of EMBP were detected by radioimmunoassay in human brain-tumor tissue. The EMBP concentrations (expressed as ng/mg protein) in 16 astrocytomas (mean 2.6 ng/mg, range 0.5 to 6.2 ng/mg) and seven meningiomas (mean 5.1 ng/mg, range 0.3 to 9.3 ng/mg) were significantly higher than that found in four samples of epileptic brain (mean 0.7 ng/mg, range 0.5 to 1 ng/mg) and 18 samples of normal brain (mean 0.5 ng/mg, range 0.2 to 1.0 ng/mg). The uptake, metabolism, and antiproliferative effects of the prostatic anticancer agent estramustine have been previously demonstrated in cultured glioma cells. The presence of EMBP may suggest a selective binding and effectiveness in human brain-tumor tissue. |
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Authors:
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E von Schoultz; T Bergenheim; K Grankvist; R Henriksson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neurosurgery Volume: 74 ISSN: 0022-3085 ISO Abbreviation: J. Neurosurg. Publication Date: 1991 Jun |
Date Detail:
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Created Date: 1991-06-21 Completed Date: 1991-06-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0253357 Medline TA: J Neurosurg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 962-4 Citation Subset: AIM; IM |
Affiliation:
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Department of Oncology, University Hospital, Umeå, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Astrocytoma
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metabolism Brain / metabolism* Brain Neoplasms / metabolism* Carrier Proteins / metabolism* Epilepsy / metabolism Estramustine / metabolism* Female Glioma / metabolism Humans Male Meningeal Neoplasms / metabolism Meningioma / metabolism Prostatic Hyperplasia / metabolism Prostatic Secretory Proteins* Radioimmunoassay Reference Values |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Prostatic Secretory Proteins; 0/estramustine-binding protein; 2998-57-4/Estramustine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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