| Estradiol supplementation during the luteal phase of in vitro fertilization cycles: a prospective randomised study. | |
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MedLine Citation:
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PMID: 21067858 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To find the optimal dosage of estradiol (E2) for luteal phase support through the addition of different doses of E2 to progeserone (P) luteal phase support in patients undergoing long GnRH agonist in vitro fertilization (IVF) treatments. STUDY DESIGN: Two hundred and eighty-five women undergoing IVF treatment with a long GnRH agonist protocol were prospectively randomized into three groups. Group 1 (n = 95) received P and 2mg E2, group 2 (n = 95) received P and 4 mg E2 and group 3 (n = 95) received P and 6 mg E2 as luteal phase support. The primary outcome was the clinical pregnancy rate (PR). The secondary variables of interest were the implantation rate (IR), miscarriage rate and multiple PR. RESULTS: The clinical PR was 31.6%, 40% and 32% respectively in groups 1, 2 and 3 and the differences between groups were not statistically significant. However, the miscarriage rate was significantly lower in group 2 (2.6%) than in group 1 (20%) but was not significantly lower than in group 3 (9.6%). CONCLUSION: For luteal phase support, adding 2, 4 or 6 mg of oral E2 to P creates no statistical difference in terms of pregnancy rates. However, a significantly higher miscarriage rate was found when 2mg E2 was used. Therefore, in the luteal phase support, 4 mg of oral estradiol in addition to progesterone can be considered to reduce the miscarriage rate. CONDENSATION: For luteal phase support, adding 2, 4 or 6 mg of oral estradiol to progesterone showed no statistical difference in terms of pregnancy and implantation rates, but a significantly higher miscarriage rate was found when 2mg estradiol was used. |
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Authors:
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Esra Tonguc; Turgut Var; Sebnem Ozyer; Ayse Citil; Muammer Dogan |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2010-11-09 |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 154 ISSN: 1872-7654 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-14 Completed Date: 2011-06-01 Revised Date: 2011-08-25 |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 172-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. esratonguc@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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chemically induced Adolescent Adult Estradiol / administration & dosage*, adverse effects Female Fertilization in Vitro / methods Humans Luteal Phase / drug effects* Ovulation Induction / methods* Pregnancy Pregnancy Rate Progesterone / administration & dosage |
| Chemical | |
Reg. No./Substance:
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50-28-2/Estradiol; 57-83-0/Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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