Document Detail

Estradiol and progesterone supplementation during luteal phase improved the receptivity of the endometrium in a patient with a history of diethylstilboestrol exposure in-utero.
MedLine Citation:
PMID:  16807227     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Diethylstilboestrol (DES) exposure in-utero has been shown to have negative effects on pregnancy. DES-exposed women are at increased risk of early spontaneous pregnancy loss, ectopic gestation and infertility. DESIGN: A 34-year old woman with a 6-year history of primary infertility is presented. The patient underwent in vitro fertilization (IVF) treatment without success. To improve the quality of the endometrium following IVF treatment, E2 and progesterone supplementation was added to the usual therapeutic regimen. The pregnancy progressed uneventfully and a normal female was born. CONCLUSIONS: This case indicates that the administration of E2 and progesterone in DES-exposed women might improve endometrium receptivity and consequently pregnancy outcome.
Dimitris Loutradis; Konstantinos Stefanidis; Erasmia Kiapekou; Evangelia Zapanti; Chrisoula Panitsa-Faflia; Aristidis Antsaklis
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Hormones (Athens, Greece)     Volume:  5     ISSN:  1109-3099     ISO Abbreviation:  Hormones (Athens)     Publication Date:    2006 Apr-Jun
Date Detail:
Created Date:  2006-06-29     Completed Date:  2006-12-01     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  101142469     Medline TA:  Hormones (Athens)     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  147-50     Citation Subset:  IM    
First Department of Obstetrics and Gynaecology, Athens University School of Medicine, Alexandra Hospital, Athens, Greece.
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MeSH Terms
Diethylstilbestrol / adverse effects*
Endometrium / drug effects*
Estradiol / therapeutic use*
Hysterosalpingography / methods
Infertility / chemically induced,  drug therapy
Luteal Phase / drug effects*
Maternal Exposure / adverse effects
Prenatal Exposure Delayed Effects / drug therapy*
Progesterone / therapeutic use*
Reg. No./Substance:
50-28-2/Estradiol; 56-53-1/Diethylstilbestrol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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