| Estradiol and progesterone supplementation during luteal phase improved the receptivity of the endometrium in a patient with a history of diethylstilboestrol exposure in-utero. | |
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MedLine Citation:
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PMID: 16807227 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Diethylstilboestrol (DES) exposure in-utero has been shown to have negative effects on pregnancy. DES-exposed women are at increased risk of early spontaneous pregnancy loss, ectopic gestation and infertility. DESIGN: A 34-year old woman with a 6-year history of primary infertility is presented. The patient underwent in vitro fertilization (IVF) treatment without success. To improve the quality of the endometrium following IVF treatment, E2 and progesterone supplementation was added to the usual therapeutic regimen. The pregnancy progressed uneventfully and a normal female was born. CONCLUSIONS: This case indicates that the administration of E2 and progesterone in DES-exposed women might improve endometrium receptivity and consequently pregnancy outcome. |
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Authors:
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Dimitris Loutradis; Konstantinos Stefanidis; Erasmia Kiapekou; Evangelia Zapanti; Chrisoula Panitsa-Faflia; Aristidis Antsaklis |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Hormones (Athens, Greece) Volume: 5 ISSN: 1109-3099 ISO Abbreviation: Hormones (Athens) Publication Date: 2006 Apr-Jun |
Date Detail:
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Created Date: 2006-06-29 Completed Date: 2006-12-01 Revised Date: 2008-03-17 |
Medline Journal Info:
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Nlm Unique ID: 101142469 Medline TA: Hormones (Athens) Country: Greece |
Other Details:
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Languages: eng Pagination: 147-50 Citation Subset: IM |
Affiliation:
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First Department of Obstetrics and Gynaecology, Athens University School of Medicine, Alexandra Hospital, Athens, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Diethylstilbestrol / adverse effects* Endometrium / drug effects* Estradiol / therapeutic use* Female Humans Hysterosalpingography / methods Infertility / chemically induced, drug therapy Luteal Phase / drug effects* Maternal Exposure / adverse effects Pregnancy Prenatal Exposure Delayed Effects / drug therapy* Progesterone / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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50-28-2/Estradiol; 56-53-1/Diethylstilbestrol; 57-83-0/Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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