Document Detail


Estradiol and progesterone regulate the migration of mast cells from the periphery to the uterus and induce their maturation and degranulation.
MedLine Citation:
PMID:  21203555     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Mast cells (MCs) have long been suspected as important players for implantation based on the fact that their degranulation causes the release of pivotal factors, e.g., histamine, MMPs, tryptase and VEGF, which are known to be involved in the attachment and posterior invasion of the embryo into the uterus. Moreover, MC degranulation correlates with angiogenesis during pregnancy. The number of MCs in the uterus has been shown to fluctuate during menstrual cycle in human and estrus cycle in rat and mouse indicating a hormonal influence on their recruitment from the periphery to the uterus. However, the mechanisms behind MC migration to the uterus are still unknown.
METHODOLOGY/PRINCIPAL FINDINGS: We first utilized migration assays to show that MCs are able to migrate to the uterus and to the fetal-maternal interface upon up-regulation of the expression of chemokine receptors by hormonal changes. By using a model of ovariectomized animals, we provide clear evidences that also in vivo, estradiol and progesterone attract MC to the uterus and further provoke their maturation and degranulation.
CONCLUSION/SIGNIFICANCE: We propose that estradiol and progesterone modulate the migration of MCs from the periphery to the uterus and their degranulation, which may prepare the uterus for implantation.
Authors:
Federico Jensen; Mariana Woudwyk; Ana Teles; Katja Woidacki; Florin Taran; Serban Costa; Sara Fill Malfertheiner; Ana Claudia Zenclussen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-12-22
Journal Detail:
Title:  PloS one     Volume:  5     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2010  
Date Detail:
Created Date:  2011-01-04     Completed Date:  2011-07-05     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e14409     Citation Subset:  IM    
Affiliation:
Experimental Obstetrics & Gynecology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany. federico.jensen@med.ovgu.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Degranulation
Cell Movement
Chemokines / metabolism
Estradiol / metabolism*
Estrus / metabolism
Female
Humans
Mast Cells / cytology*,  metabolism
Mice
Neovascularization, Physiologic
Pregnancy
Progesterone / metabolism*
Rats
Trophoblasts / metabolism
Uterus / metabolism*
Chemical
Reg. No./Substance:
0/Chemokines; 50-28-2/Estradiol; 57-83-0/Progesterone
Comments/Corrections

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