| Estradiol in the male rat amygdala facilitates mounting but not ejaculation. | |
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MedLine Citation:
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PMID: 12834795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mating activates estrogen sensitive neurons in several regions of male rat brain, including the medial amygdala (MEA). Infusion of the aromatase inhibitor, Fadrozole, into the MEA reduced mating, presumably by inhibiting conversion of testosterone (T) to estradiol (E(2)). We investigated whether administering E(2) locally into the amygdala (AMG) would maintain sexual behavior in male rats given systemic Fadrozole to eliminate E(2) elsewhere in the brain. Gonadally intact male rats were divided into two matched groups, based on ejaculatory performance in weekly tests with receptive females. All males received 0.29 mg/kg/day sc Fadrozole and bilateral implants to AMG. E(2)-in-AMG males (N=6 experimentals) received implants tipped with a cured mixture of E(2) in Silastic Medical Adhesive, whereas Vehicle-in-AMG males (N=6 controls) received implants tipped with cured adhesive alone (without E(2)). In E(2)-in-AMG males, postoperative mount and intromission frequency did not differ significantly from pretreatment baseline levels, but ejaculation frequency declined significantly (P<.01). Conversely, in Vehicle-in-AMG males, postoperative mounts and intromissions (P<.01) and ejaculations (P<.01) declined significantly. Postoperative mount and intromission frequency of Vehicle-in-AMG males was significantly lower than that of E(2)-in-AMG males (P<.01), but ejaculation frequency did not differ significantly between groups. This suggests that E(2)-sensitive AMG neurons are important for sexual arousal but not ejaculatory performance. |
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Authors:
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Gloria G Huddleston; Richard P Michael; Doris Zumpe; Andrew N Clancy |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Physiology & behavior Volume: 79 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-07-01 Completed Date: 2003-10-29 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: United States |
Other Details:
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Languages: eng Pagination: 239-46 Citation Subset: IM |
Affiliation:
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Department of Biology, MSC 8L0389, Georgia State University, 33 Gilmer Street S E Unit 8, Atlanta, GA 30303-3088, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amygdala
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metabolism,
physiology* Animals Drug Implants Ejaculation / drug effects*, physiology* Estradiol / administration & dosage*, pharmacokinetics Estrogen Antagonists / pharmacology Fadrozole / pharmacology Female Male Rats Rats, Sprague-Dawley Sexual Behavior, Animal / drug effects*, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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MH 19506/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Drug Implants; 0/Estrogen Antagonists; 102676-47-1/Fadrozole; 50-28-2/Estradiol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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