Document Detail


Estradiol in the male rat amygdala facilitates mounting but not ejaculation.
MedLine Citation:
PMID:  12834795     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mating activates estrogen sensitive neurons in several regions of male rat brain, including the medial amygdala (MEA). Infusion of the aromatase inhibitor, Fadrozole, into the MEA reduced mating, presumably by inhibiting conversion of testosterone (T) to estradiol (E(2)). We investigated whether administering E(2) locally into the amygdala (AMG) would maintain sexual behavior in male rats given systemic Fadrozole to eliminate E(2) elsewhere in the brain. Gonadally intact male rats were divided into two matched groups, based on ejaculatory performance in weekly tests with receptive females. All males received 0.29 mg/kg/day sc Fadrozole and bilateral implants to AMG. E(2)-in-AMG males (N=6 experimentals) received implants tipped with a cured mixture of E(2) in Silastic Medical Adhesive, whereas Vehicle-in-AMG males (N=6 controls) received implants tipped with cured adhesive alone (without E(2)). In E(2)-in-AMG males, postoperative mount and intromission frequency did not differ significantly from pretreatment baseline levels, but ejaculation frequency declined significantly (P<.01). Conversely, in Vehicle-in-AMG males, postoperative mounts and intromissions (P<.01) and ejaculations (P<.01) declined significantly. Postoperative mount and intromission frequency of Vehicle-in-AMG males was significantly lower than that of E(2)-in-AMG males (P<.01), but ejaculation frequency did not differ significantly between groups. This suggests that E(2)-sensitive AMG neurons are important for sexual arousal but not ejaculatory performance.
Authors:
Gloria G Huddleston; Richard P Michael; Doris Zumpe; Andrew N Clancy
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  79     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-01     Completed Date:  2003-10-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  239-46     Citation Subset:  IM    
Affiliation:
Department of Biology, MSC 8L0389, Georgia State University, 33 Gilmer Street S E Unit 8, Atlanta, GA 30303-3088, USA.
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MeSH Terms
Descriptor/Qualifier:
Amygdala / metabolism,  physiology*
Animals
Drug Implants
Ejaculation / drug effects*,  physiology*
Estradiol / administration & dosage*,  pharmacokinetics
Estrogen Antagonists / pharmacology
Fadrozole / pharmacology
Female
Male
Rats
Rats, Sprague-Dawley
Sexual Behavior, Animal / drug effects*,  physiology*
Grant Support
ID/Acronym/Agency:
MH 19506/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Drug Implants; 0/Estrogen Antagonists; 102676-47-1/Fadrozole; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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