| Estradiol, estriol, progesterone, prolactin, and human chorionic gonadotropin in pregnant women with alcohol abuse. | |
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MedLine Citation:
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PMID: 3782429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serum estradiol, estriol, progesterone, PRL, and hCG concentrations were measured at 4-week intervals in 40 pregnant women who chronically abused alcohol and in 20 abstinent pregnant women. Sixteen alcohol users gave birth to infants with the fetal alcohol syndrome (FAS), whereas the remaining 24 infants of alcohol users and all infants of the abstinent women were healthy. The women whose infants had the FAS had decreased estradiol and estriol levels throughout pregnancy. Progesterone levels also tended to be low. In contrast, the alcohol users had increased PRL levels during the 16-24th weeks of pregnancy compared with those in the abstinent women, but this rise was not related to the FAS. The concentrations of hCG fluctuated widely, without any consistent difference between alcohol users and abstinent women. Thus, heavy maternal abuse of alcohol resulting in FAS is accompanied, primarily or secondarily, by reduced estrogen concentrations throughout pregnancy and increased PRL levels during the 16-24th weeks of pregnancy. |
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Authors:
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E Halmesmäki; I Autti; M L Granström; U H Stenman; O Ylikorkala |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 64 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 1987 Jan |
Date Detail:
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Created Date: 1987-01-16 Completed Date: 1987-01-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 153-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alcoholism / blood* Chorionic Gonadotropin / blood* Estradiol / blood Estriol / blood Estrogens / blood* Female Fetal Alcohol Syndrome / etiology Humans Pregnancy / blood* Progesterone / blood* Prolactin / blood* |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/Estrogens; 50-27-1/Estriol; 50-28-2/Estradiol; 57-83-0/Progesterone; 9002-62-4/Prolactin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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