Document Detail


Estradiol decreases the orexigenic effect of neuropeptide Y, but not agouti-related protein, in ovariectomized rats.
MedLine Citation:
PMID:  18453005     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Available data suggest that estradiol exerts an inhibitory effect on food intake by modulating the actions of multiple gut- and brain-derived peptides implicated in the control of food intake. For example, recent studies have shown that estradiol decreases the orexigenic effects of ghrelin and melanin-concentrating hormone. In the present study, we examined estradiol's ability to decrease the actions of two additional orexigenic peptides, neuropeptide Y (NPY) and agouti-related protein (AgRP). Food intake was monitored following lateral ventricular infusions of 5 microg NPY, 10 microg AgRP, or saline vehicle in ovariectomized rats treated with either 1 microg estradiol or sesame oil vehicle. NPY increased food intake for 2h in both oil- and estradiol-treated ovariectomized rats. During this interval, the orexigenic effect of NPY was significantly greater in oil-treated rats, relative to estradiol-treated rats. In contrast to the short-term action of NPY, a single injection of AgRP increased food intake for 3 days in oil- and estradiol-treated rats. Meal pattern analysis revealed that the orexigenic effect of AgRP is mediated by an increase in meal size, not meal number. Unlike that observed following NPY treatment, estradiol failed to modulate the magnitude by which AgRP increased food intake and meal size. We conclude that a physiological regimen of estradiol treatment decreases the orexigenic effect of NPY, but not AgRP, in ovariectomized rats.
Authors:
Jessica Santollo; Lisa A Eckel
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-03-25
Journal Detail:
Title:  Behavioural brain research     Volume:  191     ISSN:  0166-4328     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-05-26     Completed Date:  2008-09-24     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  173-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Agouti-Related Protein / pharmacology*
Analysis of Variance
Animals
Appetite Regulation / drug effects*
Behavior, Animal / drug effects
Eating / drug effects
Estradiol / pharmacology*
Estrogens / pharmacology*
Feeding Behavior / drug effects
Female
Neuropeptide Y / pharmacology*
Ovariectomy / methods
Rats
Rats, Long-Evans
Grant Support
ID/Acronym/Agency:
DK-073936/DK/NIDDK NIH HHS; R01 DK073936/DK/NIDDK NIH HHS; R01 DK073936-02/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Agouti-Related Protein; 0/Estrogens; 0/Neuropeptide Y; 4TI98Z838E/Estradiol
Comments/Corrections

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