Document Detail

Estradiol administration after trauma-hemorrhage improves cardiovascular and hepatocellular functions in male animals.
MedLine Citation:
PMID:  11066139     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether female sex steroids have any salutary effects on the depressed cardiovascular and hepatocellular functions following trauma and hemorrhage in male animals. SUMMARY BACKGROUND DATA: Studies indicate that gender difference exists in the immune and cardiovascular responses to trauma-hemorrhage, and that male sex steroids appear to be responsible for producing immune and organ dysfunction, but it remains unknown if female sex steroids produce any salutary effects on the depressed cellular and organ functions in males following trauma and hemorrhage. METHOD: Adult male Sprague-Dawley rats underwent a midline laparotomy (i.e., trauma induction), and were bled to and maintained at a mean arterial pressure of 40 mmHg until 40% of the maximum bleed-out volume was returned in the form of Ringer's lactate (RL). Animals were then resuscitated with RL at 4 times the shed blood over 60 minutes. 17beta-estradiol (50 microg/kg) or an equal volume of vehicle was injected subcutaneously 15 minutes before the end of resuscitation. The maximal rate of ventricular pressure increase or decrease (+/-dP/dtmax), cardiac output, and hepatocellular function (i.e., maximal velocity and overall efficiency of in vivo indocyanine green clearance) were assessed at 24 hours after hemorrhage and resuscitation. Plasma levels of interleukin (IL)-6 were also measured. RESULTS: Left ventricular performance, cardiac output, and hepatocellular function decreased significantly at 24 hours after trauma-hemorrhage and resuscitation. Plasma levels of IL-6 were elevated. Administration of 17beta-estradiol significantly improved cardiac performance, cardiac output, and hepatocellular function, and attenuated the increase in plasma IL-6 levels. CONCLUSION: Administration of estrogen appears to be a useful adjunct for restoring cardiovascular and hepatocellular functions after trauma-hemorrhage in male rats.
Y Mizushima; P Wang; D Jarrar; W G Cioffi; K I Bland; I H Chaudry
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of surgery     Volume:  232     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-11-28     Completed Date:  2000-11-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  673-9     Citation Subset:  AIM; IM    
Center for Surgical Research and Department of Surgery, Brown University School of Medicine and Rhode Island Hospital, Providence, Rhode Island, USA.
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MeSH Terms
Analysis of Variance
Cardiac Output / drug effects
Coloring Agents / pharmacokinetics
Estradiol / pharmacology,  therapeutic use*
Hemodynamics / drug effects*
Hemorrhage / drug therapy*,  physiopathology*
Indocyanine Green / pharmacokinetics
Interleukin-6 / blood
Liver / drug effects*,  metabolism,  physiopathology
Rats, Sprague-Dawley
Regression Analysis
Ventricular Dysfunction, Left / physiopathology
Wounds and Injuries / drug therapy*,  physiopathology*
Grant Support
Reg. No./Substance:
0/Coloring Agents; 0/Interleukin-6; 3599-32-4/Indocyanine Green; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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