Document Detail

Estradiol and metabolic syndrome in older italian men: The InCHIANTI Study.
MedLine Citation:
PMID:  19059904     Owner:  NLM     Status:  MEDLINE    
The increasing prevalence of metabolic syndrome (MS) with age in older men has been linked with decreasing testosterone levels. Interestingly, while testosterone levels decline with age, estradiol (E2) levels remain relatively stable, resulting in a decreased testosterone:E2 ratio. Because E2 levels tend to be elevated in morbid obesity, insulin resistance, and diabetes, it is reasonable to hypothesize that high E2 levels are associated with MS in older men. We studied the relationship of total and free E2 with MS after adjustment for multiple confounders, including age, BMI, smoking, alcohol consumption, physical activity, interleukin-6 (IL-6), fasting insulin, and testosterone. Men 65 years or older (age range, 65-96; n = 452) had complete data on E2, testosterone, fasting insulin, sex hormone-binding globulin, IL-6, and albumin. Concentrations of free E2 and free testosterone were calculated using the mass action equations. MS was defined according to Adult Treatment Panel III (ATP-III). Participants with MS had significantly higher serum free and total E2 (P < .001) (P = .003). After adjusting for confounders, including age, smoking, alcohol consumption, physical activity, log(IL-6), and log(insulin), participants with higher log(total E2) (odds ratio [OR], 2.31; 95% confidence interval [95% CI], 1.39-4.70; P = .02) and higher log(free E2) (OR, 2.69; 1.38-5.24; P < .001) had an increased risk of having MS. Log(free E2) (P = .04) maintained significant correlation with MS, even after further adjustment for BMI. In older men, high E2 is independently associated with MS. Whether confirmed in other studies, assessment of E2 should be also considered in older men. Whether changes in this hormonal pattern play a role in the development of MS should be further tested in longitudinal studies.
Marcello Maggio; Fulvio Lauretani; Gian Paolo Ceda; Stefania Bandinelli; Shehzad Basaria; Giuseppe Paolisso; Claudio Giumelli; Michele Luci; Samer S Najjar; E Jeffrey Metter; Giorgio Valenti; Jack Guralnik; Luigi Ferrucci
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2008-12-04
Journal Detail:
Title:  Journal of andrology     Volume:  31     ISSN:  1939-4640     ISO Abbreviation:  J. Androl.     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-03-19     Completed Date:  2010-06-14     Revised Date:  2013-06-04    
Medline Journal Info:
Nlm Unique ID:  8106453     Medline TA:  J Androl     Country:  United States    
Other Details:
Languages:  eng     Pagination:  155-62     Citation Subset:  IM    
Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, 43100 Parma, Italy.
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MeSH Terms
Aged, 80 and over
Aging / physiology*
Estradiol / blood*
Insulin / blood
Interleukin-6 / blood
Metabolic Syndrome X / metabolism*
Serum Albumin / analysis
Sex Hormone-Binding Globulin / analysis
Testosterone / blood
Grant Support
263 MD 821336/MD/NIMHD NIH HHS; 263 MD 9164 13/MD/NIMHD NIH HHS; N01 AG821336/AG/NIA NIH HHS; N01 AG916413/AG/NIA NIH HHS; N01-AG-821336/AG/NIA NIH HHS; N01-AG-916413/AG/NIA NIH HHS
Reg. No./Substance:
0/Insulin; 0/Interleukin-6; 0/Serum Albumin; 0/Sex Hormone-Binding Globulin; 50-28-2/Estradiol; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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