Document Detail


Estradiol increases the anorectic effect of central apolipoprotein A-IV.
MedLine Citation:
PMID:  20484461     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Estrogens have potent suppressive effects on food intake and body weight in many species, including humans. Compelling evidence suggests estrogen's anorectic action is through an indirect mechanism by enhancing the strength of other physiological signals that reduce meal size such as apolipoprotein A-IV (apo A-IV), a satiation factor from the gut and brain. We determined whether estradiol, the primary form of estrogen, modulates the anorectic effect of apo A-IV. Intrafourth ventricular administration of low doses of apo A-IV reduced food intake to a greater extent in ovariectomized (OVX) rats cyclically treated with estradiol than in vehicle-treated OVX controls, implying that cyclic estradiol replacement increases the satiating potency of apo A-IV. OVX significantly increased food intake and body weight but decreased apo A-IV gene expression in the nucleus tractus solitarius (NTS). All of these alterations were reversed by cyclic regimen of estradiol treatment. The finding of colocalization of apo A-IV with estrogen receptor-alpha in the NTS suggests that estradiol might act locally in the NTS to up-regulate apo A-IV gene expression. Finally, OVX apo A-IV knockout mice had a smaller feeding response to estradiol because they ate significantly more food and gained more body weight than OVX wild-type controls during the period of cyclic estradiol replacement. These data indicate that an increased signaling of endogenous apo A-IV may partially mediate estradiol-induced inhibitory effect on feeding.
Authors:
Ling Shen; David Q-H Wang; Chun-Min Lo; Patrick Tso; W Sean Davidson; Stephen C Woods; Min Liu
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-05-19
Journal Detail:
Title:  Endocrinology     Volume:  151     ISSN:  1945-7170     ISO Abbreviation:  Endocrinology     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-23     Completed Date:  2010-07-05     Revised Date:  2013-03-28    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3163-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45237-0507, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apolipoproteins A / genetics,  metabolism,  pharmacology*,  physiology*
Body Weight / drug effects,  genetics
Eating / drug effects,  genetics
Estradiol / pharmacology*
Estrogen Receptor alpha / metabolism
Female
Immunohistochemistry
Mice
Mice, Knockout
Ovariectomy
Rats
Rats, Long-Evans
Grant Support
ID/Acronym/Agency:
DK 63907/DK/NIDDK NIH HHS; DK 70992/DK/NIDDK NIH HHS; DK17844/DK/NIDDK NIH HHS; DK54012/DK/NIDDK NIH HHS; DK73917/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoproteins A; 0/Estrogen Receptor alpha; 0/apolipoprotein A-IV; 50-28-2/Estradiol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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