| Estradiol increases the anorectic effect of central apolipoprotein A-IV. | |
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MedLine Citation:
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PMID: 20484461 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Estrogens have potent suppressive effects on food intake and body weight in many species, including humans. Compelling evidence suggests estrogen's anorectic action is through an indirect mechanism by enhancing the strength of other physiological signals that reduce meal size such as apolipoprotein A-IV (apo A-IV), a satiation factor from the gut and brain. We determined whether estradiol, the primary form of estrogen, modulates the anorectic effect of apo A-IV. Intrafourth ventricular administration of low doses of apo A-IV reduced food intake to a greater extent in ovariectomized (OVX) rats cyclically treated with estradiol than in vehicle-treated OVX controls, implying that cyclic estradiol replacement increases the satiating potency of apo A-IV. OVX significantly increased food intake and body weight but decreased apo A-IV gene expression in the nucleus tractus solitarius (NTS). All of these alterations were reversed by cyclic regimen of estradiol treatment. The finding of colocalization of apo A-IV with estrogen receptor-alpha in the NTS suggests that estradiol might act locally in the NTS to up-regulate apo A-IV gene expression. Finally, OVX apo A-IV knockout mice had a smaller feeding response to estradiol because they ate significantly more food and gained more body weight than OVX wild-type controls during the period of cyclic estradiol replacement. These data indicate that an increased signaling of endogenous apo A-IV may partially mediate estradiol-induced inhibitory effect on feeding. |
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Authors:
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Ling Shen; David Q-H Wang; Chun-Min Lo; Patrick Tso; W Sean Davidson; Stephen C Woods; Min Liu |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-05-19 |
Journal Detail:
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Title: Endocrinology Volume: 151 ISSN: 1945-7170 ISO Abbreviation: Endocrinology Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-23 Completed Date: 2010-07-05 Revised Date: 2013-03-28 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
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Languages: eng Pagination: 3163-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45237-0507, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apolipoproteins A / genetics, metabolism, pharmacology*, physiology* Body Weight / drug effects, genetics Eating / drug effects, genetics Estradiol / pharmacology* Estrogen Receptor alpha / metabolism Female Immunohistochemistry Mice Mice, Knockout Ovariectomy Rats Rats, Long-Evans |
| Grant Support | |
ID/Acronym/Agency:
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DK 63907/DK/NIDDK NIH HHS; DK 70992/DK/NIDDK NIH HHS; DK17844/DK/NIDDK NIH HHS; DK54012/DK/NIDDK NIH HHS; DK73917/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins A; 0/Estrogen Receptor alpha; 0/apolipoprotein A-IV; 50-28-2/Estradiol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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