| Estimation with Tc-99m tetrofosmin SPECT of salvaged myocardial mass after emergent reperfusion therapy in acute myocardial infarction. | |
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MedLine Citation:
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PMID: 14971619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The purpose of this study was to validate a new quantitative index of salvaged myocardial mass calculated from Tc-99m tetrofosmin SPECT for evaluating the therapeutic effect of emergent reperfusion therapy in acute myocardial infarction (AMI). METHODS: Tc-99m tetrofosmin SPECT was performed before and after emergent percutaneous transluminal coronary angioplasty (PTCA) in eight patients with AMI. In the pre-PTCA study, Tc-99m tetrofosmin was injected before emergent PTCA. Two weeks after the PTCA, post-PTCA study was performed. As a quantitative index of salvaged myocardial mass, salvaged myocardial volume (SMV) was defined as the difference of myocardial functional volume between the SPECT studies before and after the PTCA. To investigate the clinical significance of SMV, SMV was compared with the grade of therapeutic efficacy determined visually from pre- and post-PTCA SPECT images and clinical parameters, namely peak creatine phosphokinase level (pCK) and the time from the onset of the AMI to reperfusion (RPT). RESULTS: SMV showed a significant correlation with the visual grade of therapeutic efficacy (r = 0.737, p < 0.037) and a trend toward significant correlation with pCK (r = -0.622, p < 0.1). SMVs in early- and late-reperfusion groups (RPT < or = 6 hr and RPT > 6 hr) were 30.0 +/- 14.0 and -6.2 +/- 25.5 ml, showing a greater mean SMV value in the early-reperfusion group (p < 0.07). CONCLUSION: SMV could be used as a quantitative index of salvaged myocardial mass for evaluating the therapeutic effect of emergent reperfusion therapy. |
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Authors:
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Atsutaka Okizaki; Noriyuki Shuke; Tsutomu Fujita; Hiroaki Koshiyama; Morio Enomoto; Seiji Yamazaki; Takahiro Nigo; Tamiko Kurihara; Tamio Aburano |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies |
Journal Detail:
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Title: Annals of nuclear medicine Volume: 17 ISSN: 0914-7187 ISO Abbreviation: Ann Nucl Med Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2004-02-19 Completed Date: 2004-09-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8913398 Medline TA: Ann Nucl Med Country: Japan |
Other Details:
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Languages: eng Pagination: 717-23 Citation Subset: IM |
Affiliation:
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Department of Radiology, Asahikawa Medical College, Japan. okizaki@eolas-net.ne.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Angioplasty, Transluminal, Percutaneous Coronary / adverse effects* Female Humans Image Interpretation, Computer-Assisted / methods* Male Middle Aged Myocardial Infarction / complications, radionuclide imaging*, surgery* Myocardial Reperfusion Injury / etiology, radionuclide imaging* Myocardial Stunning / etiology, radionuclide imaging Organophosphorus Compounds / diagnostic use* Organotechnetium Compounds / diagnostic use* Radiopharmaceuticals / diagnostic use Reproducibility of Results Sensitivity and Specificity Severity of Illness Index Statistics as Topic Tomography, Emission-Computed, Single-Photon / methods* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Organophosphorus Compounds; 0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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