| Estimation of volatile N-nitrosamines in rubber nipples for babies' bottles. | |
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MedLine Citation:
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PMID: 6891679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A method is described for the estimation of volatile N-nitrosamines in the rubber nipples of babies' bottles. In a study of rubber nipples from one manufacturer, N-nitrosodimethylamine, N-nitrosodiethylamine and N-nitrosopiperidine were determined by gas chromatography, using a thermal energy analyser, and their presence was confirmed by mass spectrometry with average levels of individual nitrosamines ranging from 22 to 281 ppb. When the nipples were sterilized in a conventional sterilizer together with milk or infant formula the three nitrosamines migrated into the milk or formula. Storing a bottle of milk with a rubber nipple inverted in it for 2 hr at room temperature or overnight in a refrigerator after sterilization resulted in an 8-13% average increase in the nitrosamine levels migrating into the milk. On repeated sterilization of a single nipple, the quantities of nitrosamines migrating into milk from rubber nipples declined steadily, but after seven sterilizations, nitrosamines were still readily detectable in the milk. Nitrosamine levels were higher in rubber nipples after sterilization, indicating the presence of nitrosamine precursors in the nipples. No nitrosamines were found in raw, uncured rubber. Chemical accelerators and stabilizers added during the vulcanization process are the source of the amine precursors in rubber nipples. |
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Authors:
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D C Havery; T Fazio |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 20 ISSN: 0278-6915 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 1982 Dec |
Date Detail:
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Created Date: 1983-04-15 Completed Date: 1983-04-15 Revised Date: 2006-03-13 |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 939-44 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bottle Feeding* Humans Infant Infant Food Infant, Newborn Nitrosamines / isolation & purification* Rubber / analysis* Volatilization |
| Chemical | |
Reg. No./Substance:
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0/Nitrosamines; 9006-04-6/Rubber |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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