Document Detail


Estimation of variation among individuals of biological half-time of cadmium calculated from accumulation data.
MedLine Citation:
PMID:  7729385     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
For heavy metals, many experimental studies using animals have revealed short biological half-times (BHTs) to be 1 year or less by administration of heavy metals. Tsuchiya and Sugita, however, devised an original method and first reported the possibility of a long BHT for cadmium (Cd) calculated from Cd accumulation in postmortem human organs and tissues by age using a nonlinear regression analysis employing a differential equation. According to their reports, the estimated values of Cd BHT were 12.1-22.7 years in the kidney. The estimated Cd BHTs are point estimators. The point estimator of Cd BHT has been used indiscriminately to derive safety levels for Cd in the air of work environments or foodstuffs in the general population without taking into consideration individual variation of Cd BHT. In the present study, the estimated variation among individuals of Cd BHT ranges from a few years to at least 100 years in the kidney. It is concluded that the estimated average BHT according to mathematical calculation should not be used indiscriminately to derive the safety level of cadmium exposure.
Authors:
M Sugita; K Tsuchiya
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental research     Volume:  68     ISSN:  0013-9351     ISO Abbreviation:  Environ. Res.     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-05-30     Completed Date:  1995-05-30     Revised Date:  2006-10-30    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  31-7     Citation Subset:  IM    
Affiliation:
Department of Environmental and Occupational Health, Toho University School of Medicine, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Cadmium / adverse effects,  analysis,  pharmacokinetics*
Child
Child, Preschool
Data Collection
Female
Half-Life
Humans
Infant
Infant, Newborn
Kidney / chemistry,  metabolism*
Male
Mathematics
Middle Aged
Regression Analysis
Chemical
Reg. No./Substance:
7440-43-9/Cadmium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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