Document Detail


Estimation of the total daily oral intake of NDMA attributable to drinking water.
MedLine Citation:
PMID:  17878549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Disinfection with chlorine and chloramine leads to the formation of many disinfection by-products including N-Nitrosodimethylamine (NDMA). Because NDMA is a probable human carcinogen, public health officials are concerned with its occurrence in drinking water. The goal of this study was to estimate NDMA concentrations from exogenous (i.e., drinking water and food) and endogenous (i.e., formed in the human body) sources, calculate average daily doses for ingestion route exposures and estimate the proportional oral intake (POI) of NDMA attributable to the consumption of drinking water relative to other ingestion sources of NDMA. The POI is predicted to be 0.02% relative to exogenous and endogenous NDMA sources combined. When only exogenous sources are considered, the POI was predicted to be 2.7%. The exclusion of endogenously formed NDMA causes the POI to increase dramatically, reflecting its importance as a potentially major source of exposure and uncertainty in the model. Although concentrations of NDMA in foods are small and human exposure to NDMA from foods is quite low, the contribution from food is predicted to be high relative to that of drinking water. The mean concentration of NDMA in drinking water would need to increase from 2.1 x 10(-3) microg/L to 0.10 microg/L, a 47-fold increase, for the POI to reach 1%, relative to all sources of NDMA considered in our model, suggesting that drinking water consumption is most likely a minor source of NDMA exposure.
Authors:
Anthony Fristachi; Glenn Rice
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of water and health     Volume:  5     ISSN:  1477-8920     ISO Abbreviation:  J Water Health     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-19     Completed Date:  2007-11-05     Revised Date:  2009-09-18    
Medline Journal Info:
Nlm Unique ID:  101185420     Medline TA:  J Water Health     Country:  England    
Other Details:
Languages:  eng     Pagination:  341-55     Citation Subset:  IM    
Affiliation:
Oak Ridge Institute for Science and Education assigned to US Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Cincinnati, OH 45268, USA. afristac@jhsph.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
Child, Preschool
Dimethylnitrosamine
Drinking
Eating
Environmental Exposure / analysis*
Environmental Monitoring
Food Contamination / analysis
Humans
Infant
Infant Formula / chemistry
Infant, Newborn
Nitrosamines / analysis*,  metabolism
Water Pollutants, Chemical / analysis*
Water Supply / analysis*
Chemical
Reg. No./Substance:
0/Nitrosamines; 0/Water Pollutants, Chemical; 62-75-9/Dimethylnitrosamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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