Document Detail

Estimation of the time of pulmonary metastasis in colorectal cancer patients with isolated synchronous liver metastasis.
MedLine Citation:
PMID:  15681599     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to estimate the time when pulmonary metastases began to grow in colorectal cancer (CRC) patients with isolated synchronous liver metastasis based on the tumor doubling time (DT). METHODS: We examined 23 pulmonary metastases in 14 patients detected after resection of liver metastases from CRC (group 1) and 19 pulmonary metastases in eight patients detected after initiation of hepatic arterial infusion chemotherapy for synchronous unresectable liver metastases (group 2). The regression line was determined from the chest X-ray films, and the DT was calculated. RESULTS: We estimated the DTs of pulmonary metastases as 65.0 +/- 28.9 and 76.2 +/- 23.0 days in groups 1 and 2, respectively, and the time when pulmonary metastases began to grow as 16-1418 and 112-1464 days before the resection of liver metastases for 19 lesions in 12 out of 14 patients of group 1 and before resection of primary CRC in group 2, respectively. CONCLUSION: It appears that in some CRC patients in whom the metastatic site is considered to be limited to the liver at diagnosis, occult pulmonary metastasis has already taken place.
Sotaro Sadahiro; Toshiyuki Suzuki; Kenji Ishikawa; Tomoki Nakamura; Yoichi Tanaka; Kazuhiro Ishizu; Seiei Yasuda; Hiroyasu Makuuchi; Chieko Murayama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese journal of clinical oncology     Volume:  35     ISSN:  0368-2811     ISO Abbreviation:  Jpn. J. Clin. Oncol.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-31     Completed Date:  2005-03-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0313225     Medline TA:  Jpn J Clin Oncol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  18-22     Citation Subset:  IM    
Department of Surgery, Tokai University, Bohseidai Isehara, Kanagawa 259-1193, Japan.
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MeSH Terms
Antimetabolites, Antineoplastic / administration & dosage
Cell Division / physiology
Colorectal Neoplasms / pathology*,  surgery
Fluorouracil / administration & dosage
Hepatic Artery
Infusions, Intra-Arterial
Liver Neoplasms / drug therapy,  pathology,  secondary*,  surgery
Lung Neoplasms / pathology,  secondary*
Neoplasms, Multiple Primary
Retrospective Studies
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 51-21-8/Fluorouracil

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