Document Detail

Estimation of the target stem-cell population size in chronic myeloid leukemogenesis.
MedLine Citation:
PMID:  10525957     Owner:  NLM     Status:  MEDLINE    
Estimation of the number of hematopoietic stem cells capable of causing chronic myeloid leukemia (CML) is relevant to the development of biologically based risk models of radiation-induced CML. Through a comparison of the age structure of CML incidence data from the Surveillance, Epidemiology, and End Results (SEER) Program and the age structure of chromosomal translocations found in healthy subjects, the number of CML target stem cells is estimated for individuals above 20 years of age. The estimation involves three steps. First, CML incidence among adults is fit to an exponentially increasing function of age. Next, assuming a relatively short waiting time distribution between BCR-ABL induction and the appearance of CML, an exponential age function with rate constants fixed to the values found for CML is fitted to the translocation data. Finally, assuming that translocations are equally likely to occur between any two points in the genome, the parameter estimates found in the first two steps are used to estimate the number of target stem cells for CML. The population-averaged estimates of this number are found to be 1.86x10(8) for men and 1.21x10(8) for women; the 95% confidence intervals of these estimates are (1.34x10(8), 2. 50x10(8)) and (0.84x10(8), 1.83x10(8)), respectively.
T Radivoyevitch; M J Ramsey; J D Tucker
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Radiation and environmental biophysics     Volume:  38     ISSN:  0301-634X     ISO Abbreviation:  Radiat Environ Biophys     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-11-17     Completed Date:  1999-11-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0415677     Medline TA:  Radiat Environ Biophys     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  201-6     Citation Subset:  IM    
Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA.
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MeSH Terms
Aged, 80 and over
Child, Preschool
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / epidemiology*,  pathology
Middle Aged
Neoplastic Stem Cells / pathology*
Translocation, Genetic

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