Document Detail

Estimation of the stillbirth rate in twin pairs according to zygosity.
MedLine Citation:
PMID:  17564509     Owner:  NLM     Status:  MEDLINE    
It is common opinion that the stillbirth rate is higher among monozygotic (MZ) than among dizygotic (DZ) twins. This is supported by the fact that stillbirth rates are higher among same-sexed than among opposite-sexed twins, and the relatively high stillbirth rates among twins of young mothers. In this study we present a method to estimate the stillbirth rates for MZ and DZ twins and identify the difference. We performed analyses based on the assumptions of (a) Weinberg's differential rule, including the assumption that the secondary sex ratio is 100, (b) the stillbirth rates among opposite-sexed twins hold for all DZ twins, and (c) the stillbirth rates estimated for MZ and DZ male and female twins yield for both sexes the observed total number of stillborn twins. Our methods are applied to data from Sweden, 1869-1967, the Aland Islands, 1750-1949, Saxony, 1881-1900, and England and Wales, 1996-2003. We observed that the ratio between the estimated stillbirth rates among MZ and DZ twins were on average 1.75, and the ratio among same-sexed and DZ (opposite-sexed) twins were on average 1.31. For Sweden and Saxony similar values were obtained, but for England and Wales the values were higher and for Aland lower. With exception of Aland, the estimated stillbirth rates were in all populations the lowest for DZ, medium for same-sexed and highest for MZ twins.
Johan Fellman; Aldur W Eriksson
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Publication Detail:
Type:  Historical Article; Journal Article; Research Support, Non-U.S. Gov't; Twin Study    
Journal Detail:
Title:  Twin research and human genetics : the official journal of the International Society for Twin Studies     Volume:  10     ISSN:  1832-4274     ISO Abbreviation:  -     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-13     Completed Date:  2007-08-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101244624     Medline TA:  Twin Res Hum Genet     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  508-13     Citation Subset:  IM    
Folkhälsan Institute of Genetics, Population Genetics Unit, Helsinki, Finland.
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MeSH Terms
Cohort Studies
History, 18th Century
History, 19th Century
History, 20th Century
Infant, Newborn
Pregnancy Complications
Prospective Studies
Sex Characteristics
Stillbirth / epidemiology,  genetics*
Survival Analysis
Twins, Dizygotic / genetics*
Twins, Monozygotic / genetics*

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