| Estimation of rac-Amisulpride Transfer into Milk and of Infant Dose via Milk During Its Use in a Lactating Woman with Bipolar Disorder and Schizophrenia. | |
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MedLine Citation:
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PMID: 20925494 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Abstract This case describes the transfer of the antipsychotic drug amisulpride into milk and the estimation of infant exposure via breastfeeding. The dyad investigated was a 28-year-old lactating woman and her 13-month-old daughter. The woman had been taking 400 mg of amisulpride daily for 9 days and provided eight milk samples and one blood sample over a 24-hour dose interval. Amisulpride concentrations in these samples were measured by high-performance liquid chromatography, and infant dose was calculated by standard methods. The infant's health and progress were evaluated by a neonatal pediatrician. Transfer of amisulpride into milk was high, with a milk:plasma distribution ratio of 19.5 (5,188 μg/L in milk and 266 μg/L in plasma). The average amisulpride concentration in milk was 3,562 μg/L, which, when multiplied by an average milk intake of 0.15 L/kg/day, gave an absolute infant dose of 534 μg/kg/day. The relative infant dose was 10.7% of the maternal weight-adjusted dose (5,000 μg/kg/day), which is slightly above the usual 10% safety recommendation. The infant was in good health with an appropriate Denver development score for her age. She showed no acute drug-related adverse effects. Given that the infant had already benefited from 13 months of breastfeeding, that amisulpride has potential adverse effects, and that its relative infant dose was 10.7%, we recommended cessation of breastfeeding in the near-term. |
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Authors:
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Stephanie Teoh; Kenneth F Ilett; L Peter Hackett; Rolland Kohan |
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Publication Detail:
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Type: Journal Article Date: 2010-10-06 |
Journal Detail:
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Title: Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine Volume: 6 ISSN: 1556-8342 ISO Abbreviation: Breastfeed Med Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101260777 Medline TA: Breastfeed Med Country: United States |
Other Details:
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Languages: eng Pagination: 85-8 Citation Subset: IM |
Affiliation:
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1 Department of Pharmacy, King Edward Memorial Hospital , Women and Newborn Health Services, Subiaco, Australia . |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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