| Estimation of postmortem metabolic changes in porcine brain tissue using 1H-MR spectroscopy--preliminary results. | |
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MedLine Citation:
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PMID: 15578198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the potential for estimating the time since death by monitoring the evolution of different metabolites in brain tissue by (1)H-MRS, an animal model using pig heads was established. The maximum examination interval was 3 weeks. Within this time interval spectra revealed different compositions of metabolites, including metabolites observed in the normal brain and as products of bacterial decomposition processes (N-acetyl-aspartate 0-130 h, creatine 0-170 h, bound trimethylammonium, e. g. choline compounds, during the whole time course with fluctuating intensities, lactate 0-200 h, alanine and acetate during the whole time course, succinate and free trimethylammonium after approx. 100 h postmortem). The proposed approach may offer a new method to estimate later postmortem intervals although these observations have to be confirmed by further studies. |
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Authors:
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S Banaschak; R Rzanny; J R Reichenbach; W A Kaiser; A Klein |
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Publication Detail:
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Type: Journal Article Date: 2004-12-01 |
Journal Detail:
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Title: International journal of legal medicine Volume: 119 ISSN: 0937-9827 ISO Abbreviation: Int. J. Legal Med. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-03-03 Completed Date: 2005-11-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9101456 Medline TA: Int J Legal Med Country: Germany |
Other Details:
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Languages: eng Pagination: 77-9 Citation Subset: IM |
Affiliation:
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Institute of Legal Medicine, Fürstengraben 23, 07743 Jena, Germany. Sibylle.Banaschak@med.uni-jena.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetates
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metabolism Amino Acids / metabolism Animals Brain / metabolism* Choline / metabolism Forensic Pathology Lactic Acid / metabolism Magnetic Resonance Spectroscopy* Models, Animal Postmortem Changes* Swine |
| Chemical | |
Reg. No./Substance:
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0/Acetates; 0/Amino Acids; 50-21-5/Lactic Acid; 62-49-7/Choline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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