| Estimation of perfusion and arterial transit time in myocardium using free-breathing myocardial arterial spin labeling with navigator-echo. | |
| | |
MedLine Citation:
|
PMID: 20865753 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Arterial spin labeling (ASL) provides noninvasive measurement of tissue blood flow, but sensitivity to motion has limited its application to imaging of myocardial blood flow. Although different cardiac phases can be synchronized using electrocardiography triggering, breath holding is generally required to minimize effects of respiratory motion during ASL scanning, which may be challenging in clinical populations. Here a free-breathing myocardial ASL technique with the potential for reliable clinical application is presented, by combining ASL with a navigator-gated, electrocardiography-triggered TrueFISP readout sequence. Dynamic myocardial perfusion signals were measured at multiple delay times that allowed simultaneous fitting of myocardial blood flow and arterial transit time. With the assist of a nonrigid motion correction program, the estimated mean myocardial blood flow was 1.00 ± 0.55 mL/g/min with a mean transit time of ∼ 400 msec. The intraclass correlation coefficient of repeated scans was 0.89 with a mean within subject coefficient of variation of 22%. Perfusion response during mild to moderate stress was further measured. The capability for noninvasive, free-breathing assessment of myocardial blood flow using ASL may offer an alternative approach to first-pass perfusion MRI for clinical evaluation of patients with coronary artery disease. |
| | |
Authors:
|
Danny J J Wang; Xiaoming Bi; Brian B Avants; Tongbai Meng; Sven Zuehlsdorff; John A Detre |
Related Documents
:
|
2097303 - Reproducibility of mean transit time for maximal myocardial flow assessment by videoden... 10336923 - Validation of minimally invasive measurement of myocardial perfusion using electron bea... 2624783 - Is cerebral blood flow/metabolic mismatch during rewarming a risk factor after profound... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 64 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-10-28 Completed Date: 2011-03-08 Revised Date: 2011-12-16 |
Medline Journal Info:
|
Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
|
Languages: eng Pagination: 1289-95 Citation Subset: IM |
Copyright Information:
|
© 2010 Wiley-Liss, Inc. |
Affiliation:
|
Department of Neurology, Ahmanson-Lovelace Brain Mapping Center, University of California at Los Angeles, Los Angeles, California 90095-7085, USA. jwang71@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Algorithms* Cardiac-Gated Imaging Techniques / methods* Computer Simulation Coronary Circulation / physiology* Female Humans Image Enhancement / methods* Image Interpretation, Computer-Assisted / methods* Male Middle Aged Models, Cardiovascular* Myocardial Perfusion Imaging / methods* Reproducibility of Results Respiratory Mechanics Sensitivity and Specificity Spin Labels Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
MH080892/MH/NIMH NIH HHS; P41 RR002305-20S10061/RR/NCRR NIH HHS; P41 RR002305-236856/RR/NCRR NIH HHS; P41 RR002305-246007/RR/NCRR NIH HHS; P41 RR002305-255538/RR/NCRR NIH HHS; R01 MH080892-01A2/MH/NIMH NIH HHS; R01 MH080892-01A2S1/MH/NIMH NIH HHS; R01 MH080892-03/MH/NIMH NIH HHS; R01 MH080892-04/MH/NIMH NIH HHS; RR002305/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Spin Labels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Multicomponent T2* mapping of knee cartilage: technical feasibility ex vivo.
Next Document: Ionic liquid-bonded polysiloxane as stationary phase for capillary gas chromatography.