Document Detail


Estimation of oxygen metabolism in a rat model of permanent ischemia using positron emission tomography with injectable15O-O2.
MedLine Citation:
PMID:  16552423     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The threshold of cerebral blood flow (CBF) into infarction in rats has been indicated to be similar to that in patients. However, CBF does not reflect metabolic function, and so estimations of oxygen metabolism have been required. Here, we estimated changes in oxygen metabolism after occluding the right middle cerebral artery (MCA) in rats using an injectable (15)O-O(2) we developed. A decrease in CBF (left: 0.67+/-0.22 mL/min/g, right: 0.44+/-0.17 mL/min/g, P<0.05) and compensatory increase in the oxygen extraction fraction (OEF) (left: 0.42+/-0.13, right: 0.50+/-0.19, P<0.05) were observed at 1-h after occlusion. In contrast, a marked decrease in CBF and the cerebral metabolic rate for oxygen and a collapse of the compensatory OEF mechanism were found at 24 h after occlusion. Injectable (15)O-O(2) could be used to reliably estimate oxygen metabolism in an infarction rat model with positron emission tomography.
Authors:
Takashi Temma; Yasuhiro Magata; Yuji Kuge; Sayaka Shimonaka; Kohei Sano; Yumiko Katada; Hidekazu Kawashima; Takahiro Mukai; Hiroshi Watabe; Hidehiro Iida; Hideo Saji
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-03-22
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  26     ISSN:  0271-678X     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-23     Completed Date:  2006-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1577-83     Citation Subset:  IM    
Affiliation:
Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Ischemia / metabolism*,  radiography
Cerebral Arteries / radiography
Cerebrovascular Circulation*
Disease Models, Animal
Male
Oxygen / metabolism*
Oxygen Consumption*
Oxygen Radioisotopes / pharmacology
Positron-Emission Tomography* / methods
Rats
Rats, Sprague-Dawley
Time Factors
Chemical
Reg. No./Substance:
0/Oxygen Radioisotopes; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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