Document Detail


Estimation of myocardial perfusion using deuterium nuclear magnetic resonance.
MedLine Citation:
PMID:  1779725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A technique to estimate regional and/or global myocardial perfusion in-vivo was developed using deuterium nuclear magnetic resonance measurement of perdeuterated saline washout from the myocardium of 9 dogs. Washout data were fitted to a one-component plus baseline Kety-Schmidt exponential model. To assess the ability of this technique to reliably measure changes in perfusion during change in myocardial workload, norepinephrine (1 microgram/kg/min) was infused and hypoxia was induced (by increasing the inspired ratio of N2/O2 to obtain a PAO2 of 20-30 mmHg) in separate interventions. Myocardial work, as determined by heart rate X systolic blood pressure, increased during both interventions. To support this increased workload, myocardial perfusion increased during both physiological interventions. These data indicate that myocardial perfusion can now be reliably estimated with a non-radioactive, non-toxic (in the concentrations used) tracer, perdeuterated saline. The technique can be used for repeated real-time measurements of perfusion during sequential physiological interventions.
Authors:
M D Mitchell; M Osbakken
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Magnetic resonance imaging     Volume:  9     ISSN:  0730-725X     ISO Abbreviation:  Magn Reson Imaging     Publication Date:  1991  
Date Detail:
Created Date:  1992-03-11     Completed Date:  1992-03-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8214883     Medline TA:  Magn Reson Imaging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  545-52     Citation Subset:  IM; S    
Affiliation:
Department of Biochemistry/Biophysics, School of Medicine, University of Pennsylvania, Philadelphia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia / physiopathology
Blood Pressure / drug effects,  physiology
Coronary Circulation* / drug effects,  physiology
Deuterium / administration & dosage,  diagnostic use*
Dogs
Female
Heart Rate / drug effects,  physiology
Magnetic Resonance Spectroscopy / diagnostic use*,  methods
Male
Norepinephrine / pharmacology
Oxygen Consumption / drug effects,  physiology
Perfusion
Spectrum Analysis
Stroke Volume / drug effects,  physiology
Grant Support
ID/Acronym/Agency:
R01 HL39208-02/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
51-41-2/Norepinephrine; 7782-39-0/Deuterium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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