Document Detail

Estimation of minimum alveolar concentration (MAC) for halothane, enflurane and isoflurane in spontaneously breathing guinea pigs.
MedLine Citation:
PMID:  2593635     Owner:  NLM     Status:  MEDLINE    
MAC for halothane, enflurane and isoflurane was determined in guinea pigs (Cavia porcellus) exposed to constant anesthetic concentrations (2.5 hours each) in a flow-through glass chamber. The following values were obtained (N = 8 for each anesthetic): 1.01 +/- 0.03 vol% for halothane, 2.17 +/- 0.04 vol% for enflurane, and 1.15 +/- 0.05 vol% for isoflurane. In guinea pigs, MAC for halothane and enflurane are similar to those reported for other rodents, while MAC for isoflurane is lower. The data indicate that guinea pigs possibly are more susceptible to isoflurane's anesthetic actions than other rodents.
A B Seifen; R H Kennedy; J P Bray; E Seifen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Laboratory animal science     Volume:  39     ISSN:  0023-6764     ISO Abbreviation:  Lab. Anim. Sci.     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1990-01-17     Completed Date:  1990-01-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1266503     Medline TA:  Lab Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  579-81     Citation Subset:  IM    
Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock.
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MeSH Terms
Anesthesia / veterinary
Enflurane / analysis*
Guinea Pigs / metabolism*
Halothane / analysis*
Isoflurane / analysis*
Pulmonary Alveoli / analysis*
Reg. No./Substance:
13838-16-9/Enflurane; 151-67-7/Halothane; 26675-46-7/Isoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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