| Estimation of liver function using T2* mapping on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid enhanced magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 21514080 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: To investigate the usefulness of T2* mapping of liver on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI for estimating liver function. MATERIALS AND METHODS: 33 patients were classified into 3 groups as follows: normal liver function (NLF) (n=7); mild liver damage (MLD) (n=16) with Child-Pugh A; severe liver damage (SLD) (n=10) with Child-Pugh B. T2*-weighted gradient-echo (T2*W-GRE) and T1-weighted gradient-echo (T1W-GRE) images were obtained before and after Gd-EOB-DTPA administration (3, 8, 13, and 18min; 5, 10,15, and 20min; respectively). T2* mapping of liver was calculated from T2*W-GRE, then T2* values of liver and T2* reduction rates of T2* value between pre- and post-contrast enhancement were measured. The increase rates of liver-to-muscle signal intensity (LMS) ratio on T1W-GRE between pre- and post-contrast enhancement were calculated. RESULTS: T2* values on pre- and post-contrast showed no significant differences among three groups. Significant differences in T2* reduction rates were found among groups, and those of LCB were lower than those of other groups (NLF:MLD:SLD, 3.8:6.0:0.6% at 3min, 8.2:10.3:1.0% at 8min, 10.7:11.5:1.2% at 13min, and 16.1:13.2:3.5% at 18min, respectively) (P<0.05). Significant differences in increase rates of LMS ratio on T1W-GRE were identified (NLF:MLD:SLD, 1.53:1.46:1.35 at 5min, 1.68:1.64:1.37 at 10min, 1.79:1.76:1.44 at 15min, and 1.89:1.78:1.49 at 20min, respectively). CONCLUSION: T2* reduction rate and increase rate of LMS ratio on T1W-GRE may allow us estimation of liver function according to Child-Pugh score. |
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Authors:
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Takashi Katsube; Masahiro Okada; Seishi Kumano; Izumi Imaoka; Yuki Kagawa; Masatoshi Hori; Kazunari Ishii; Noboru Tanigawa; Yasuharu Imai; Masatoshi Kudo; Takamichi Murakami |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-20 |
Journal Detail:
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Title: European journal of radiology Volume: - ISSN: 1872-7727 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106411 Medline TA: Eur J Radiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Radiology, Shimane University School of Medicine, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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