| Estimation of the lipophilic character of flavonoids from the retention behavior in reversed phase liquid chromatography on different stationary phases: A comparative study. | |
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MedLine Citation:
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PMID: 21945453 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The retention behavior of some flavonoids in reversed phase liquid chromatography (RPLC) was investigated using different chemistries of the modified silicagel based stationary phases. Highly end-capped octadecyl silicagel (ODS), polar embedded linker octadecyl silicagel (SB-18 Aqua), phenyl silicagel and pentafluorophenyl modified silicagel (PFP) were used as stationary phases. The mobile phase consisted in acetonitrile/acidified water mixtures, at different fractions of volume. The lipophilicity was estimated through different chromatographic descriptors, as it follows: logk(w), mlogk, S, φ(0) and PC1/logk. The chromatographic behavior observed on the mentioned stationary phases was evaluated by means of various graphical profiles and correlation matrices. Additionally, new information about the characteristics of the stationary phases and their (dis)-similarities were provided through lipophilicity charts and by scatterplots of loadings obtained by applying principal component analysis (PCA) to retention data. Furthermore, the experimental lipophilicity indices estimated from retention data were correlated with the computed descriptors, at a high level of statistical significance. |
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Authors:
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Florentin Tache; Rodica Domnica Naşcu-Briciu; Costel Sârbu; Florina Micăle; Andrei Medvedovici |
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Publication Detail:
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Type: - Date: 2011-9-8 |
Journal Detail:
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Title: Journal of pharmaceutical and biomedical analysis Volume: - ISSN: 1873-264X ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309336 Medline TA: J Pharm Biomed Anal Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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University of Bucharest, Faculty of Chemistry, Department of Analytical Chemistry, Panduri Av. # 90, Bucharest 050663, Romania; Bioanalytical Laboratory, SC Labormed Pharma SA, #44B Th. Pallady Blvd., Bucharest 032266, Romania. |
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