| Estimation of intersubject variability of cerebral blood flow measurements using MRI and positron emission tomography. | |
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MedLine Citation:
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PMID: 22246715 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: To investigate the within and between subject variability of quantitative cerebral blood flow (CBF) measurements in normal subjects using various MRI techniques and positron emission tomography (PET). MATERIALS AND METHODS: Repeated CBF measurements were performed in 17 healthy, young subjects using three different MRI techniques: arterial spin labeling (ASL), dynamic contrast enhanced T1 weighted perfusion MRI (DCE) and phase contrast mapping (PCM). All MRI measurements were performed within the same session. In 10 of the subjects repeated CBF measurements by (15) O labeled water PET had recently been performed. A mixed linear model was used to estimate between subject (CV(betw) ) and within subject (CV(with) ) coefficients of variation. RESULTS: Mean global CBF, CV(betw) and CV(with) using each of the four methods were for PCM 65.2 mL/100 g/min, 17.4% and 7.4%, for ASL 37.1 mL/100 g/min, 16.2% and 4.8%, for DCE 43.0 mL/100 g/min, 20.0%, 15.1% and for PET 41.9 mL/100 g/min, 16.5% and 11.9%, respectively. Only for DCE and PCM a significant positive correlation between measurements was demonstrated. CONCLUSION: These findings confirm large between subject variability in CBF measurements, but suggest also that in healthy subjects a subject-method interaction is a possible source of between subject variability and of method differences. J. Magn. Reson. Imaging 2012;. © 2012 Wiley Periodicals, Inc. |
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Authors:
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Otto M Henriksen; Henrik B W Larsson; Adam E Hansen; Julie M Grüner; Ian Law; Egill Rostrup |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-13 |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: - ISSN: 1522-2586 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Functional Imaging Unit, Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Glostrup Hospital, Glostrup, Denmark; Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen N, Denmark. otthen01@regionh.dk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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