| Estimation of internal filtration flow rate in high-flux dialyzers by Doppler ultrasonography. | |
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MedLine Citation:
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PMID: 20938136 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Several types of dialyzer with enhanced internal filtration have been introduced for clinical application as a means of improving the efficiency of solute removal, and the enhanced internal filtration in these dialyzers has increased the convective transport of the solute besides the diffusive transport. The internal filtration flow rates (Q(IF)) of the dialyzer, however, have never been evaluated precisely. In this study, blood flow velocity in a cross-sectional plane of a dialyzer was measured by pulse Doppler ultrasonography to evaluate Q(IF). An in vitro study using bovine blood was carried out to determine the local blood flow velocity profile with a probe slider that enables the probe to move in parallel along a dialyzer. A good correlation between observed blood velocity (u(B)(0)) and blood flow rate (Q(B)(0)) at the inlet portion of the dialyzer was obtained during the in vitro study. Blood flow rate profiles along the dialyzer (Q(B)(z)) could be estimated from the product of blood velocity u(B)(z) and the total cross-sectional area of the blood flow path (S(B)) of the hollow fibers. The maximum internal filtration flow rate value (Q(IF-Max)) was estimated as Q(B)(0) - [Q(B)(z)](Min), where [Q(B)(z)](Min) is the minimum value of Q(B)(z). The Doppler ultrasonography described in this paper is a useful method for bedside monitoring of Q( IF) in several dialyzers, because it is noninvasive to the patient and produces reliable data with higher reproducibility. |
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Authors:
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Michio Mineshima |
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Publication Detail:
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Type: Journal Article Date: 2010-10-07 |
Journal Detail:
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Title: Contributions to nephrology Volume: 168 ISSN: 1662-2782 ISO Abbreviation: Contrib Nephrol Publication Date: 2011 |
Date Detail:
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Created Date: 2010-10-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7513582 Medline TA: Contrib Nephrol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 153-61 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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Department of Clinical Engineering, Tokyo Women's Medical University, Tokyo, Japan. mmine@ce.twmu.ac.jp |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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