Document Detail


Estimation of heritability for Tying-up syndrome in the Thoroughbred racehorse by Gibbs sampling.
MedLine Citation:
PMID:  16191036     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tying-up is a condition that primarily affects the muscles of horses. In this study, the heritability of the Tying-up syndrome in the Thoroughbred racehorse was estimated by Bayesian analysis with Gibbs sampling based on the threshold model for binary traits. The data used were the clinical data in racehorses diagnosed by veterinarians of the Racehorse Clinics of Japan Racing Association from 2000 to 2003. The health status of the Tying-up was treated as a binary trait. In the genetic analysis, the effect of changing the amount of the pedigree or inbreeding information on the estimation of heritability was investigated, too. The heritability estimates with non-zero probability in the posterior densities were approximately 0.16-0.18 in minimum, suggesting that the heritability of the Tying-up is not zero at least. The posterior density distributions of the heritability estimates were generally more pointed and sharp with using inbreeding coefficients than without using it, suggesting that more stable estimations were obtained when inbreeding coefficients were used. Among the different amounts of pedigree and inbreeding information, the heritabilities obtained with three or four generations of pedigree using inbreeding coefficients seems to be preferable, i.e. heritability of 0.42 or 0.43 for Tying-up.
Authors:
H Oki; T Miyake; T Hasegawa; Y Sasaki
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of animal breeding and genetics = Zeitschrift für Tierzüchtung und Züchtungsbiologie     Volume:  122     ISSN:  0931-2668     ISO Abbreviation:  J. Anim. Breed. Genet.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-29     Completed Date:  2006-02-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100955807     Medline TA:  J Anim Breed Genet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  289-93     Citation Subset:  IM    
Affiliation:
Japan Racing Association, Equine Research Institute, Utsunomiya City, Tochigi, Japan. oki@center.equinst.go.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Bayes Theorem
Breeding
Genetic Predisposition to Disease*
Horse Diseases / genetics*
Horses
Inbreeding
Japan
Models, Genetic*
Pedigree
Rhabdomyolysis / genetics,  veterinary*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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