| Estimation of fetal oxygen uptake in human term pregnancies. | |
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MedLine Citation:
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PMID: 21473676 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective. Umbilical oxygen (O(2)) uptake is a parameter of basic physiologic interest. It has been extensively studied in chronically catheterized animals but very few data have been obtained acutely in humans. Recent developments in ultrasound technology allow the estimation of umbilical venous blood flow in utero. Methods. In all, 26 normal term pregnancies were studied at the time of elective cesarean section in order to evaluate fetal O(2) uptake as the product of umbilical blood flow and umbilical O(2) veno-arterial difference. An ultrasound evaluation was performed within 1 h from delivery: umbilical vein area and flow velocity were recorded to calculate umbilical vein volume flow (Q(umb)). Blood samples from the umbilical vein (uv) and artery (ua) were obtained at the time of fetal extraction for respiratory gases and acid-base evaluation. Results. Umbilical O(2) uptake was calculated as Q(umb) • (uv-ua)O(2) content: an average value of 0.84 ± 0.40 mmol/min was obtained. Umbilical O(2) uptake per kg was 0.25 ± 0.12 mmol/kg/min, significantly related to fetal O(2) delivery. Conclusions. We estimated umbilical blood flow by ultrasound and we measured umbilical O(2) uptake at term obtaining a value of umbilical O(2) uptake/kg similar to what previously reported in human pregnancies and chronically catheterized animals. |
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Authors:
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Tatjana Radaelli; Simona Boito; Emanuela Taricco; Veronica Cozzi; Irene Cetin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-7 |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: - ISSN: 1476-4954 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Mother, Child and Neonate `L. Mangiagalli,' IRCCS Ospedale Maggiore Policlinico Mangiagalli e Regina Elena, 20122 Milan, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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