| Estimation of fetal exposure to drugs of abuse, environmental tobacco smoke, and ethanol. | |
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MedLine Citation:
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PMID: 11805717 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many women worldwide use recreational drugs and alcohol. Details on the amounts and schedule of such exposures in pregnancy are often unreliable because of recall issues and shame and fears of legal action. Even when the report on maternal dose is correct, it does not necessarily reflect the amount reaching the fetus. Drugs of abuse accumulate in meconium and are incorporated into fetal hair on its growth. Recent work has documented the sensitivity and specificity of these assays for cocaine and other recreational drugs. Dose-response relationships between cocaine as measured in neonatal hair and head circumference or neurologic sequelae have been recently established. For ethanol, which cannot be measured in hair or meconium, accumulation of its fatty acid ethyl esters in meconium is emerging as a promising test for heavy maternal drinking in the second part of pregnancy. The identification of biologic markers of intrauterine exposure to xenobiotics will allow better understanding of etiology and dose-response relationships. |
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Authors:
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Gideon Koren; Daphne Chan; Julia Klein; Tatiana Karaskov |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Therapeutic drug monitoring Volume: 24 ISSN: 0163-4356 ISO Abbreviation: Ther Drug Monit Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-01-23 Completed Date: 2002-04-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7909660 Medline TA: Ther Drug Monit Country: United States |
Other Details:
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Languages: eng Pagination: 23-5 Citation Subset: IM |
Affiliation:
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Motherisk Program, Division of Clinical Pharmacology/Toxicology, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada. gkoren@sickkids.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Central Nervous System Depressants
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analysis,
pharmacokinetics* Ethanol / analysis, pharmacokinetics* Female Fetus / metabolism* Humans Maternal Exposure* Pregnancy Street Drugs / analysis, pharmacokinetics* Substance Abuse Detection* Tobacco Smoke Pollution* |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Depressants; 0/Street Drugs; 0/Tobacco Smoke Pollution; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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