Document Detail


Estimation of fetal exposure to drugs of abuse, environmental tobacco smoke, and ethanol.
MedLine Citation:
PMID:  11805717     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many women worldwide use recreational drugs and alcohol. Details on the amounts and schedule of such exposures in pregnancy are often unreliable because of recall issues and shame and fears of legal action. Even when the report on maternal dose is correct, it does not necessarily reflect the amount reaching the fetus. Drugs of abuse accumulate in meconium and are incorporated into fetal hair on its growth. Recent work has documented the sensitivity and specificity of these assays for cocaine and other recreational drugs. Dose-response relationships between cocaine as measured in neonatal hair and head circumference or neurologic sequelae have been recently established. For ethanol, which cannot be measured in hair or meconium, accumulation of its fatty acid ethyl esters in meconium is emerging as a promising test for heavy maternal drinking in the second part of pregnancy. The identification of biologic markers of intrauterine exposure to xenobiotics will allow better understanding of etiology and dose-response relationships.
Authors:
Gideon Koren; Daphne Chan; Julia Klein; Tatiana Karaskov
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Therapeutic drug monitoring     Volume:  24     ISSN:  0163-4356     ISO Abbreviation:  Ther Drug Monit     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-01-23     Completed Date:  2002-04-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909660     Medline TA:  Ther Drug Monit     Country:  United States    
Other Details:
Languages:  eng     Pagination:  23-5     Citation Subset:  IM    
Affiliation:
Motherisk Program, Division of Clinical Pharmacology/Toxicology, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada. gkoren@sickkids.ca
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MeSH Terms
Descriptor/Qualifier:
Central Nervous System Depressants / analysis,  pharmacokinetics*
Ethanol / analysis,  pharmacokinetics*
Female
Fetus / metabolism*
Humans
Maternal Exposure*
Pregnancy
Street Drugs / analysis,  pharmacokinetics*
Substance Abuse Detection*
Tobacco Smoke Pollution*
Chemical
Reg. No./Substance:
0/Central Nervous System Depressants; 0/Street Drugs; 0/Tobacco Smoke Pollution; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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