Document Detail

Estimation of the equilibrium lateral pressure in 1-palmitoyl-2-[6(pyren-1-yl)]hexanoyl-glycerophospholipid liposomes.
MedLine Citation:
PMID:  3815626     Owner:  NLM     Status:  MEDLINE    
Compression isotherms for 1-palmitoyl-2-[6(pyren-1-yl)] hexanoyl-sn-glycero-3-phosphocholine (PPHPC), -ethanolamine (PPHPE), -glycerol (PPHPG), -serine (PPHPS) and -phosphatidic acid monomethylester (PPHPM) were recorded at an argon/water interface. Thereafter, the ratios of pyrene excimer to monomer fluorescence emission intensities (Ie/Im) were determined for liposomes of these lipids and were found to be 20.15, 12.30, 11.80, 10.15 and 6.95 for the ethanolamine, choline, monomethylester, glycerol and serine derivatives, respectively. Assuming Ie/Im to depend on the reciprocal of the mean molecular area of the pyrenelipids in liposomes, equilibrium surface pressure to be the same in liposomes of these lipids regardless of the head group structure and neglecting any possible influence due to differences in the orientation of the pyrene moiety, we sought for that surface pressure value in the compression isotherms where the correlation of the reciprocal of mean molecular area in monolayers to Ie/Im values observed in liposomes was maximal. This treatment results in a value of approximately 12 mN m-1 for the equilibrium surface pressure in 1-palmitoyl-2-[6(pyren-1-yl)]hexanoyl-glycerophospholipid liposomes.
T Thuren; J A Virtanen; P K Kinnunen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemistry and physics of lipids     Volume:  41     ISSN:  0009-3084     ISO Abbreviation:  Chem. Phys. Lipids     Publication Date:    1986 Oct-Nov
Date Detail:
Created Date:  1987-04-03     Completed Date:  1987-04-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0067206     Medline TA:  Chem Phys Lipids     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  329-34     Citation Subset:  IM    
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MeSH Terms
Models, Biological
Molecular Conformation
Spectrometry, Fluorescence
Structure-Activity Relationship
Reg. No./Substance:
0/Liposomes; 0/Phosphatidylcholines; 103625-33-8/1-palmitoyl-2-(pyren-1-yl)hexanoyl-sn-glycero-3-phosphocholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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