Document Detail

Estimation of the effect of increasing UVB exposure on the human immune system and related resistance to infectious diseases and tumours.
MedLine Citation:
PMID:  9595706     Owner:  NLM     Status:  MEDLINE    
Exposure to UV light has, besides some beneficial effects (vitamin D production), many harmful effects on human health. UVB irradiation has been shown to suppress both systemic and local immune responses to a variety of antigens, including some microorganisms. However, it is still not known whether such immunomodulating effects may lead to an increase in the number and severity of certain tumours and/or infections in humans. We report herein the data provided by a project that was funded by the European Union (Programme Environment), and that was aimed at the estimation of the risk associated with increased UVB exposure due to ozone depletion regarding the deleterious effects on the immune system and related resistance to tumours and infections in humans. The data, obtained by the different research groups involved, were assembled and used to calculate for the first time a risk assessment for increased environmental exposure to UVB in human subjects.
J Garssen; M Norval; A el-Ghorr; N K Gibbs; C D Jones; D Cerimele; C De Simone; S Caffieri; F Dall'Acqua; F R De Gruijl; Y Sontag; H Van Loveren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of photochemistry and photobiology. B, Biology     Volume:  42     ISSN:  1011-1344     ISO Abbreviation:  J. Photochem. Photobiol. B, Biol.     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-06-11     Completed Date:  1998-06-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8804966     Medline TA:  J Photochem Photobiol B     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  167-79     Citation Subset:  IM    
National Institute of Public Health, Department of Pathology and Immunobiology, Bilthoven, Netherlands.
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MeSH Terms
Communicable Diseases / immunology*
Immune System / immunology*,  radiation effects*
Immunity, Innate / radiation effects
Neoplasms / immunology*
Risk Factors
Skin / radiation effects
Skin Neoplasms / etiology
Ultraviolet Rays*

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