Document Detail

Estimation of the differential pressure at renal artery stenoses.
MedLine Citation:
PMID:  15122679     Owner:  NLM     Status:  MEDLINE    
Atherosclerotic disease of the renal artery can lead to reduction in arterial caliber and ultimately to conditions including renovascular hypertension. Renal artery stenosis is conventionally assessed, using angiography, according to the severity of the stenosis. However, the severity of a stenosis is not a reliable indicator of functional significance, or associated differential pressure, of a stenosis. A methodology is proposed for estimation of the renal artery differential pressure (RADP) from MR imaging. Realistic computational fluid dynamics (CFD) models are constructed from MR angiography (MRA) and phase-contrast (PC) MR. The CFD model is constructed in a semiautomated manner from the MR images using the Isosurface Deformable Model (IDM) for surface reconstruction and a Marching Front algorithm for construction of the volumetric CFD mesh. Validation of RADP estimation was performed in a realistic physical flow-through model. Under steady flow, the CFD estimate of the differential pressure across a stenosis in the physical flow-through model differed by an average of 5.5 mmHg from transducer measurements of the pressure differential, for differential pressures less than 60 mmHg. These results demonstrate that accurate estimates of differential pressure at stenoses may be possible based only on structural and flow images.
Peter J Yim; Juan R Cebral; Ashley Weaver; Robert J Lutz; Orlando Soto; G Boudewijn C Vasbinder; Vincent B Ho; Peter L Choyke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  51     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-03     Completed Date:  2004-08-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  969-77     Citation Subset:  IM    
Copyright Information:
Published 2004 Wiley-Liss, Inc.
UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA.
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MeSH Terms
Arteriosclerosis / physiopathology
Blood Pressure
Magnetic Resonance Angiography* / methods
Models, Anatomic
Models, Theoretical
Renal Artery Obstruction / physiopathology*

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