Document Detail

Estimation of diagnostic-test sensitivity and specificity through Bayesian modeling.
MedLine Citation:
PMID:  15820113     Owner:  NLM     Status:  MEDLINE    
We review recent Bayesian approaches to estimation (based on cross-sectional sampling designs) of the sensitivity and specificity of one or more diagnostic tests. Our primary goal is to provide veterinary researchers with a concise presentation of the computational aspects involved in using the Bayesian framework for test evaluation. We consider estimation of diagnostic-test sensitivity and specificity in the following settings: (i) one test in one population, (ii) two conditionally independent tests in two or more populations, (iii) two correlated tests in two or more populations, and (iv) three tests in two or more populations, where two tests are correlated but jointly independent of the third test. For each scenario, we describe a Bayesian model that incorporates parameters of interest. The WinBUGS code used to fit each model, which is available at, can be altered readily to conform to different data.
A J Branscum; I A Gardner; W O Johnson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Preventive veterinary medicine     Volume:  68     ISSN:  0167-5877     ISO Abbreviation:  Prev. Vet. Med.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-11     Completed Date:  2005-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8217463     Medline TA:  Prev Vet Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  145-63     Citation Subset:  IM    
Department of Statistics, University of California, One Shields Ave, Davis, CA 95616, USA.
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MeSH Terms
Bayes Theorem*
Cattle Diseases / diagnosis,  parasitology
Classical Swine Fever / diagnosis
Coccidiosis / diagnosis,  veterinary
Cross-Sectional Studies
Diagnostic Tests, Routine / methods,  standards,  veterinary*
Fish Diseases / diagnosis,  parasitology
Microsporidiosis / diagnosis,  veterinary
Models, Biological*
Oncorhynchus mykiss
Sensitivity and Specificity
Swine Diseases / diagnosis,  parasitology
Toxoplasmosis, Animal / diagnosis

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