| Estimation of delivered dialysis dose by on-line monitoring of the ultraviolet absorbance in the spent dialysate. | |
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MedLine Citation:
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PMID: 12722037 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Several methods are available to determine Kt/V, from predialysis and postdialysis blood samples to using on-line dialysate urea monitors or to ionic dialysance using a conductivity method. The aim of this study is to compare Kt/V calculated from the slope of the logarithmic on-line ultraviolet (UV) absorbance measurements, blood urea Kt/V, dialysate urea Kt/V, and Kt/V from the Urea Monitor 1000 (UM; Baxter Healthcare Corp, Deerfield, IL). METHODS: Thirteen uremic patients on chronic thrice-weekly hemodialysis therapy were included in the study. The method uses absorption of UV radiation by means of a spectrophotometric set-up. Measurements were performed on-line with the spectrophotometer connected to the fluid outlet of the dialysis machine; all spent dialysate passed through a specially designed cuvette for optical single-wavelength measurements. UV absorbance measurements were compared with those calculated using blood urea and dialysate urea, and, in a subset of treatments, the UM. RESULTS: Equilibrated Kt/V (eKt/V) obtained with UV absorbance (eKt/Va) was 1.19 +/- 0.23; blood urea (eKt/Vb), 1.30 +/- 0.20, and dialysate urea (eKt/Vd), 1.26 +/- 0.21, and Kt/V in a subset measured by the UM (UM Kt/V) was 1.24 +/- 0.18. The difference between eKt/Vb and eKt/Va was 0.10 +/- 0.11, showing a variation similar to the difference between eKt/Vb and eKt/Vd (0.03 +/- 0.10) and in a subset between eKt/Vb and UM Kt/V (-0.02 +/- 0.11). CONCLUSION: The study suggests that urea Kt/V can be estimated by on-line measurement of UV absorption in the spent dialysate. |
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Authors:
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Fredrik Uhlin; Ivo Fridolin; Lars-Göran Lindberg; Martin Magnusson |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 41 ISSN: 1523-6838 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-04-30 Completed Date: 2004-01-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: United States |
Other Details:
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Languages: eng Pagination: 1026-36 Citation Subset: IM |
Affiliation:
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Department of Nephrology University Hospital, Linköping, Sweden. fredrik.uhlin@lio.se |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Adult Aged Aged, 80 and over Female Hemodialysis Solutions / administration & dosage*, pharmacokinetics Humans Male Middle Aged Monitoring, Physiologic / instrumentation, methods Renal Dialysis Spectrophotometry, Ultraviolet Ultraviolet Rays Urea / blood* Uremia / metabolism, therapy |
| Chemical | |
Reg. No./Substance:
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0/Hemodialysis Solutions; 57-13-6/Urea |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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