| Estimation of daily exposure to 4-hydroxy-2-alkenals in Korean foods containing n-3 and n-6 polyunsaturated fatty acids. | |
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MedLine Citation:
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PMID: 16147425 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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4-Hydroxy-2-alkenals are cytotoxic aldehydes generated from the oxidation of n-3 and n-6 polyunsaturated fatty acids. The compounds have shown various biological effects via Schiff base adducts or Michael addition adducts at levels higher than physiological ones. To assess human exposure to 4-hydroxy-2-alkenals in the diet, 4-hydroxy-2-alkenals in vegetable oils, fish and shellfish were monitored using GC/MS/SIM. 2001 National Health and Nutrition Survey (2002) data were employed for the dietary intake pattern. The Korean daily exposure to 4-hydroxy-2-alkenals, excluding a possible one from fried food, was 4.3 microg day-1, constituted of 1.6 microg 4-hydroxy-2-hexenal (HHE) and 2.7 microg 4-hydroxy-2-nonenal (HNE). It was calculated that Koreans could be additionally exposed to more than 11.8 microg day-1 4-hydroxy-2-alkenal from fried foods. Thus, the combined exposure would be 16.1 microg day-1, which corresponds to 0.3 microg kg-1 body weight day-1 for a 60 kg Korean adult. In spite of the biological toxicity of 4-hydroxy-2-alkenals, the risk for human could not be quantified due to the lack of a virtually safe dose of the compounds. However, considering the basal level of 4-hydroxy-2-alkenals in many tissues, the present value from the diet may not pose a significant risk for human health. |
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Authors:
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J Surh; H Kwon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Food additives and contaminants Volume: 22 ISSN: 0265-203X ISO Abbreviation: Food Addit Contam Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-09-08 Completed Date: 2005-11-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8500474 Medline TA: Food Addit Contam Country: England |
Other Details:
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Languages: eng Pagination: 701-8 Citation Subset: IM |
Affiliation:
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Department of Food and Nutrition, Seoul National University, San 56-1, Sillim-dong, Gwanak-gu, Seoul 151-742, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aldehydes / analysis* Animals Fatty Acids, Unsaturated / analysis* Fishes / metabolism Food Analysis / methods* Humans Korea Nutrition Surveys Plant Oils / analysis Risk Assessment / methods Shellfish / analysis |
| Chemical | |
Reg. No./Substance:
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0/Aldehydes; 0/Fatty Acids, Unsaturated; 0/Plant Oils; 17427-08-6/4-hydroxy-2-hexenal; 29343-52-0/4-hydroxy-2-nonenal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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