| Estimation of circulating blood volume in infants using the pulse dye densitometry method. | |
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MedLine Citation:
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PMID: 15675929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Estimation of hemodynamics is important for critically ill infants. Pulse dye densitometry (PDD) using indocyanine green (ICG), which enables measurements of circulating blood volume at the bedside, has recently been developed for adults. METHODS: We conducted a basic investigation to determine whether this method can be applied to infants and measured circulating blood volume in 25 infants whose gestational ages ranged from 24 to 40 weeks (median, 32 weeks). At first, to validate the accuracy of measurements, arterial ICG concentrations determined by blood sample measurements were compared using a spectrophotometer ([ICG blood]) and by noninvasive measurement using PDD ([ICG pdd]) in seven infants. Next, blood volumes in 25 infants were estimated by the PDD method. RESULTS: There was a positive relationships between [ICG blood] and [ICG pdd] (r = 0.913, P < 0.0001). Using Bland Altman analysis, the bias between the two methods was 0.24 +/- 0.30 mg.l(-1) (95% confidence interval: 0.39-0.09 mg.l(-1)) and the limits of agreement (2 sd) were -0.36 and 0.84 mg.l(-1), respectively. Mean (sd) blood volume was 94.9 ml.kg(-1) (24.3). The values obtained by this study are almost the same as previously reported values obtained by using other methods. CONCLUSIONS: PDD using ICG can be used to monitor of hemodynamics in infants. |
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Authors:
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Keiko Nagano; Takashi Kusaka; Kensuke Okubo; Saneyuki Yasuda; Hitoshi Okada; Masanori Namba; Kou Kawada; Tadashi Imai; Kenichi Isobe; Susumu Itoh |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Paediatric anaesthesia Volume: 15 ISSN: 1155-5645 ISO Abbreviation: Paediatr Anaesth Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-01-28 Completed Date: 2005-07-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9206575 Medline TA: Paediatr Anaesth Country: France |
Other Details:
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Languages: eng Pagination: 125-30 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure
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physiology Blood Volume / physiology* Coloring Agents / administration & dosage Densitometry / methods Dye Dilution Technique* Hemoglobins / analysis Humans Indocyanine Green / administration & dosage Infant Infant, Newborn Linear Models Reproducibility of Results Sensitivity and Specificity Spectrophotometry / methods |
| Chemical | |
Reg. No./Substance:
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0/Coloring Agents; 0/Hemoglobins; 3599-32-4/Indocyanine Green |
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