Document Detail

Estimation of circulating blood volume in infants using the pulse dye densitometry method.
MedLine Citation:
PMID:  15675929     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Estimation of hemodynamics is important for critically ill infants. Pulse dye densitometry (PDD) using indocyanine green (ICG), which enables measurements of circulating blood volume at the bedside, has recently been developed for adults. METHODS: We conducted a basic investigation to determine whether this method can be applied to infants and measured circulating blood volume in 25 infants whose gestational ages ranged from 24 to 40 weeks (median, 32 weeks). At first, to validate the accuracy of measurements, arterial ICG concentrations determined by blood sample measurements were compared using a spectrophotometer ([ICG blood]) and by noninvasive measurement using PDD ([ICG pdd]) in seven infants. Next, blood volumes in 25 infants were estimated by the PDD method. RESULTS: There was a positive relationships between [ICG blood] and [ICG pdd] (r = 0.913, P < 0.0001). Using Bland Altman analysis, the bias between the two methods was 0.24 +/- 0.30 mg.l(-1) (95% confidence interval: 0.39-0.09 mg.l(-1)) and the limits of agreement (2 sd) were -0.36 and 0.84 mg.l(-1), respectively. Mean (sd) blood volume was 94.9 (24.3). The values obtained by this study are almost the same as previously reported values obtained by using other methods. CONCLUSIONS: PDD using ICG can be used to monitor of hemodynamics in infants.
Keiko Nagano; Takashi Kusaka; Kensuke Okubo; Saneyuki Yasuda; Hitoshi Okada; Masanori Namba; Kou Kawada; Tadashi Imai; Kenichi Isobe; Susumu Itoh
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Paediatric anaesthesia     Volume:  15     ISSN:  1155-5645     ISO Abbreviation:  Paediatr Anaesth     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-01-28     Completed Date:  2005-07-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9206575     Medline TA:  Paediatr Anaesth     Country:  France    
Other Details:
Languages:  eng     Pagination:  125-30     Citation Subset:  IM    
Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan.
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MeSH Terms
Blood Pressure / physiology
Blood Volume / physiology*
Coloring Agents / administration & dosage
Densitometry / methods
Dye Dilution Technique*
Hemoglobins / analysis
Indocyanine Green / administration & dosage
Infant, Newborn
Linear Models
Reproducibility of Results
Sensitivity and Specificity
Spectrophotometry / methods
Reg. No./Substance:
0/Coloring Agents; 0/Hemoglobins; 3599-32-4/Indocyanine Green

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