Document Detail

Estimation of cardiac output by first-pass transit of radiotracers.
MedLine Citation:
PMID:  10582798     Owner:  NLM     Status:  MEDLINE    
To evaluate cardiac function with various tracers to be used for radionuclide scintigraphy, we examined the validity of a simplified method to measure cardiac output (CO) by modifying the equation of Stewart-Hamilton in the radionuclide study. After a bolus injection of I-123 or Tc-99m tracer, the total injection dose and count in the pulmonary artery during the first transit of the tracer were measured to calculate the CO Index. The CO Index was obtained from the integral of the first transit of radiotracers in the pulmonary artery divided by the total injected count. CO was estimated from the regression formula which was obtained by comparing the CO Index with CO measured by the Doppler echocardiographic method. There were close correlations between the CO Index and CO measured by Doppler echocardiography both in the study with I-123 (n = 13, r = 0.85, p < 0.001) and with Tc-99m (n = 17, r = 0.88, p < 0.001). The regression formula varied according to the radionuclide used for the study (CO = 2.29 x (CO Index)(0.634) for I-123 and CO = 3.18 x (CO Index)(0.518) for Tc-99m). CO measured by this method is useful for the assessment of cardiac function with various tracers in routine clinical studies, and this simple method may be utilized for assessment of organ blood flow on the basis of the microsphere model.
I T Sugihara; Y Yonekura; Y Miyazaki; Y Taniguchi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Annals of nuclear medicine     Volume:  13     ISSN:  0914-7187     ISO Abbreviation:  Ann Nucl Med     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-01-07     Completed Date:  2000-01-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8913398     Medline TA:  Ann Nucl Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  299-302     Citation Subset:  IM    
Department of Internal Medicine, Takashima General Hospital, Takashima-gun, Shiga, Japan.
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MeSH Terms
Cardiac Output*
Echocardiography, Doppler
Evaluation Studies as Topic
Heart Function Tests / methods*,  statistics & numerical data
Iofetamine / diagnostic use
Organophosphorus Compounds / diagnostic use
Organotechnetium Compounds / diagnostic use
Radioisotope Dilution Technique* / statistics & numerical data
Radiopharmaceuticals / diagnostic use*
Regional Blood Flow
Reproducibility of Results
Reg. No./Substance:
0/Organophosphorus Compounds; 0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane; 95896-48-3/Iofetamine

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