Document Detail


Estimation of baseline dopamine D2 receptor occupancy in striatum and extrastriatal regions in humans with positron emission tomography with [18F] fallypride.
MedLine Citation:
PMID:  17586476     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: This study examined whether positron emission tomography (PET) studies with [18F] fallypride performed before and after alpha-methyl-para-tyrosine (AMPT) administration can be used to estimate baseline dopamine (DA) D2 receptor occupancy in striatal and extrastriatal regions. METHODS: Six normal subjects underwent PET with [18 F] fallypride before and after administration of AMPT. The DA D2 receptor binding potentials (bp) were calculated with the reference region method. Percent changes in bp in striatal and extrastriatal regions were calculated with both region-of-interest analysis and on a voxel by voxel basis with parametric images of DA D2 receptor levels. RESULTS: The results of the current study indicate that AMPT treatment significantly increased the bp in the caudate, putamen, ventral striatum, and substantia nigra. A trend level increase was seen in the medial thalamus. CONCLUSIONS: This study demonstrates that PET with [18F] fallypride can be used to estimate baseline DA D2 receptor occupancy in striatal and extrastriatal regions.
Authors:
Patrizia Riccardi; Ron Baldwin; Ronald Salomon; Sharlet Anderson; Mohammad S Ansari; Rui Li; Benoit Dawant; Amy Bauernfeind; Dennis Schmidt; Robert Kessler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-06-27
Journal Detail:
Title:  Biological psychiatry     Volume:  63     ISSN:  1873-2402     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-31     Completed Date:  2008-02-27     Revised Date:  2008-04-02    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  241-4     Citation Subset:  IM    
Affiliation:
Department of Radiology, Vanderbilt University, Nashville, Tennessee 37232-2675, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Benzamides / metabolism*
Brain Mapping*
Corpus Striatum / radionuclide imaging*
Female
Humans
Male
Positron-Emission Tomography*
Pyrrolidines / metabolism*
Radioligand Assay
Receptors, Dopamine D2 / metabolism*
Grant Support
ID/Acronym/Agency:
5R01 MH60898-03/MH/NIMH NIH HHS; M01 RR-00095/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Benzamides; 0/N-((1-allyl-2-pyrrolidinyl)methyl)-5-(3-fluoropropyl)-2,3-dimethoxybenzamide; 0/Pyrrolidines; 0/Receptors, Dopamine D2

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