Document Detail


Estimation of arterial PCO2 from a lung model during ramp exercise in healthy young subjects.
MedLine Citation:
PMID:  17166781     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study is to propose a new approach to estimate non-invasively arterial carbon dioxide partial pressure (P(a)CO2) approach was based on the reconstruction of alveolar gas composition over each breath from a tidally ventilated lung model (P(M)(CO2)). Eight healthy young subjects were studied during a ramp exercise test on a cycle ergometer. Arterial samples were drawn at rest and every minute during the exercise test for determination of P(a)CO2 . P(a)CO2 was compared with indirect estimates of P(CO2) : P(M)(CO2), end-tidal P(CO2) (P(ET)(CO2)) and an empirical equation involving P(ET)(CO2) and tidal volume (P(J)(CO2)). The difference between estimated and measured P(a)CO2 on the whole ramp exercise was -0.3+/-1.9mmHg for P(M)(CO2), 1.0+/-2.2mmHg for P(ET)(CO2) and -1.7+/-1.7mmHg for P(J)(CO2) . P(ET)(CO2) and P(J)(CO2) were significantly different from actual P(a)CO2 (P<0.001). It is concluded that, on the basis of the bias, the breathing lung model gave better estimates of P(a)CO2 than the two other indirect methods during ramp exercise.
Authors:
Vincent Thomas; Frédéric Costes; Thierry Busso
Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2006-11-12
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  156     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-03-26     Completed Date:  2007-05-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  259-65     Citation Subset:  IM    
Affiliation:
Unité de Recherche: Physiologie et Physiopathologie de l'Exercice et Handicap, Université Jean Monnet, Saint-Etienne, France. vincent.thomas@univ-st-etienne.fr
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MeSH Terms
Descriptor/Qualifier:
Adult
Carbon Dioxide / blood*
Exercise / physiology*
Exercise Test
Humans
Lung / physiology*
Male
Models, Biological
Models, Statistical
Oxygen Consumption / physiology
Pulmonary Alveoli / metabolism
Pulmonary Gas Exchange / physiology
Reproducibility of Results
Respiratory Function Tests
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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