| Estimation of arterial PCO2 from a lung model during ramp exercise in healthy young subjects. | |
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MedLine Citation:
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PMID: 17166781 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study is to propose a new approach to estimate non-invasively arterial carbon dioxide partial pressure (P(a)CO2) approach was based on the reconstruction of alveolar gas composition over each breath from a tidally ventilated lung model (P(M)(CO2)). Eight healthy young subjects were studied during a ramp exercise test on a cycle ergometer. Arterial samples were drawn at rest and every minute during the exercise test for determination of P(a)CO2 . P(a)CO2 was compared with indirect estimates of P(CO2) : P(M)(CO2), end-tidal P(CO2) (P(ET)(CO2)) and an empirical equation involving P(ET)(CO2) and tidal volume (P(J)(CO2)). The difference between estimated and measured P(a)CO2 on the whole ramp exercise was -0.3+/-1.9mmHg for P(M)(CO2), 1.0+/-2.2mmHg for P(ET)(CO2) and -1.7+/-1.7mmHg for P(J)(CO2) . P(ET)(CO2) and P(J)(CO2) were significantly different from actual P(a)CO2 (P<0.001). It is concluded that, on the basis of the bias, the breathing lung model gave better estimates of P(a)CO2 than the two other indirect methods during ramp exercise. |
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Authors:
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Vincent Thomas; Frédéric Costes; Thierry Busso |
Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2006-11-12 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 156 ISSN: 1569-9048 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-03-26 Completed Date: 2007-05-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 259-65 Citation Subset: IM |
Affiliation:
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Unité de Recherche: Physiologie et Physiopathologie de l'Exercice et Handicap, Université Jean Monnet, Saint-Etienne, France. vincent.thomas@univ-st-etienne.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Carbon Dioxide / blood* Exercise / physiology* Exercise Test Humans Lung / physiology* Male Models, Biological Models, Statistical Oxygen Consumption / physiology Pulmonary Alveoli / metabolism Pulmonary Gas Exchange / physiology Reproducibility of Results Respiratory Function Tests |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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